Disentangling fetal insulin hypersecretion and insulin resistance

Christopher J. Nolan; Gernot Desoye

doi:10.1016/j.tem.2024.04.008

Disentangling fetal insulin hypersecretion and insulin resistance

Christopher J. Nolan^*
, Gernot Desoye

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

5 Citations (Scopus)

Abstract

Disentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.

Original language	English
Pages (from-to)	934-936
Number of pages	3
Journal	Trends in Endocrinology and Metabolism
Volume	35
Issue number	11
Early online date	1 May 2024
DOIs	https://doi.org/10.1016/j.tem.2024.04.008
Publication status	Published - Nov 2024

Access to Document

10.1016/j.tem.2024.04.008

Cite this

@article{6121ad999adf466ead54969725822d20,

title = "Disentangling fetal insulin hypersecretion and insulin resistance",

abstract = "Disentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.",

keywords = "fetus, hyperinsulinemia, insulin resistance, insulin secretion, pancreatic islet, type 2 diabetes",

author = "Nolan, \{Christopher J.\} and Gernot Desoye",

note = "{\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = nov,

doi = "10.1016/j.tem.2024.04.008",

language = "English",

volume = "35",

pages = "934--936",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "11",

}

TY - JOUR

T1 - Disentangling fetal insulin hypersecretion and insulin resistance

AU - Nolan, Christopher J.

AU - Desoye, Gernot

PY - 2024/11

Y1 - 2024/11

N2 - Disentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.

AB - Disentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.

KW - fetus

KW - hyperinsulinemia

KW - insulin resistance

KW - insulin secretion

KW - pancreatic islet

KW - type 2 diabetes

UR - https://www.scopus.com/pages/publications/85191974221

U2 - 10.1016/j.tem.2024.04.008

DO - 10.1016/j.tem.2024.04.008

M3 - Short survey

C2 - 38697899

AN - SCOPUS:85191974221

SN - 1043-2760

VL - 35

SP - 934

EP - 936

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 11

ER -

Disentangling fetal insulin hypersecretion and insulin resistance

Abstract

Access to Document

Other files and links

Fingerprint

Cite this