@article{e8ba24f0fa2647918bc95c16a80fa246,
title = "DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns",
abstract = "Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion are subject to hypermethylation. Using methylome sequencing we identified CpG islands that display partial methylation encroachment across the 5′ or 3′ CpG island borders. CpG island methylation encroachment is widespread in prostate and breast cancer and commonly associates with gene suppression. We show that the pattern of H3K4me1 at CpG island borders in normal cells predicts the different modes of cancer CpG island hypermethylation. Notably, genetic manipulation of Kmt2d results in concordant alterations in H3K4me1 levels and CpG island border DNA methylation encroachment. Our findings suggest a role for H3K4me1 in the demarcation of CpG island methylation borders in normal cells, which become eroded in cancer.",
keywords = "5-hydroxymethylation, BisChIP-seq, CpG islands, DNA methylation encroachment, H3K4 monomethylation, TAB-seq, WGBS, cancer, hypermethylation",
author = "Ksenia Skvortsova and Etienne Masle-Farquhar and Luu, {Phuc Loi} and Song, {Jenny Z.} and Wenjia Qu and Elena Zotenko and Gould, {Cathryn M.} and Qian Du and Peters, {Timothy J.} and Yolanda Colino-Sanguino and Ruth Pidsley and Nair, {Shalima S.} and Amanda Khoury and Smith, {Grady C.} and Miosge, {Lisa A.} and Reed, {Joanne H.} and Kench, {James G.} and Rubin, {Mark A.} and Lisa Horvath and Ozren Bogdanovic and Lim, {Sue Mei} and Polo, {Jose M.} and Goodnow, {Christopher C.} and Clare Stirzaker and Clark, {Susan J.}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = feb,
day = "11",
doi = "10.1016/j.ccell.2019.01.004",
language = "English",
volume = "35",
pages = "297--314.e8",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",
}