TY - JOUR
T1 - Domino Cyclization Reaction of o-Diisocyanoarenes for the Synthesis of Imidazo[1,2-a]pyridinobenzimidazole Backbones
AU - Rezaei-Gohar, Mohammad
AU - Amiri, Kamran
AU - Aghaie, Kimia
AU - Nayebzadeh, Behrouz
AU - Ariafard, Alireza
AU - Shiri, Farshad
AU - Rominger, Frank
AU - Dar’in, Dmitry
AU - Krasavin, Mikhail
AU - Balalaie, Saeed
N1 -
© 2023 The Author(s)
PY - 2023/8/4
Y1 - 2023/8/4
N2 - An efficient procedure to access a variety of connected imidazo[1,2-a]pyridine and benzimidazole skeletons through the C-N bond was described as a new type of Buchwald-Hartwig reaction. Furthermore, the bis(imidazo[1,2-a]pyridin-3-yl)aryl-1,2-diamine scaffolds were obtained by changing the equivalent ratio of the starting materials. Some advantages of the protocol are the formation of four new bonds (C═C, C-N), a transition-metal-free reaction, a broad substrate scope, high yields, and mild reaction conditions. The reaction mechanism was confirmed on the basis of DFT calculations.
AB - An efficient procedure to access a variety of connected imidazo[1,2-a]pyridine and benzimidazole skeletons through the C-N bond was described as a new type of Buchwald-Hartwig reaction. Furthermore, the bis(imidazo[1,2-a]pyridin-3-yl)aryl-1,2-diamine scaffolds were obtained by changing the equivalent ratio of the starting materials. Some advantages of the protocol are the formation of four new bonds (C═C, C-N), a transition-metal-free reaction, a broad substrate scope, high yields, and mild reaction conditions. The reaction mechanism was confirmed on the basis of DFT calculations.
UR - https://www.scopus.com/pages/publications/85166468010
U2 - 10.1021/acs.orglett.3c02137
DO - 10.1021/acs.orglett.3c02137
M3 - Article
C2 - 37487026
AN - SCOPUS:85166468010
SN - 1523-7060
VL - 25
SP - 5682
EP - 5686
JO - Organic Letters
JF - Organic Letters
IS - 30
ER -