Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials

Robert De Rose; Mark T. Sullivan; C. Jane Dale; Anthony D. Kelleher; Sean Emery; David A. Cooper; Ian A. Ramshaw; David B. Boyle; Stephen J. Kent

doi:10.4161/hv.2940

Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials

Robert De Rose, Mark T. Sullivan, C. Jane Dale, Anthony D. Kelleher, Sean Emery, David A. Cooper, Ian A. Ramshaw, David B. Boyle, Stephen J. Kent^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 × 10⁷ pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in monkeys. These data provide a rationale for guiding dosing in future trials of HIV vaccine technologies.

Original language	English
Pages (from-to)	134-136
Number of pages	3
Journal	Human Vaccines
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/hv.2940
Publication status	Published - 2006

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title = "Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials",

abstract = "Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 × 107 pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in monkeys. These data provide a rationale for guiding dosing in future trials of HIV vaccine technologies.",

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author = "{De Rose}, Robert and Sullivan, {Mark T.} and Dale, {C. Jane} and Kelleher, {Anthony D.} and Sean Emery and Cooper, {David A.} and Ramshaw, {Ian A.} and Boyle, {David B.} and Kent, {Stephen J.}",

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AU - De Rose, Robert

AU - Sullivan, Mark T.

AU - Dale, C. Jane

AU - Kelleher, Anthony D.

AU - Emery, Sean

AU - Cooper, David A.

AU - Ramshaw, Ian A.

AU - Boyle, David B.

AU - Kent, Stephen J.

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AB - Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 × 107 pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in monkeys. These data provide a rationale for guiding dosing in future trials of HIV vaccine technologies.

KW - Body surface area

KW - Immunologic dose-response relationship

KW - Prime-boost

KW - Vaccine

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Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials

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