Drosophila simulans: A species with improved resolution in evolve and resequence studies

Neda Barghi, Raymond Tobler, Viola Nolte, Christian Schlötterer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The combination of experimental evolution with high-throughput sequencing of pooled individuals-i.e., evolve and resequence (E&R)-is a powerful approach to study adaptation from standing genetic variation under controlled, replicated conditions. Nevertheless, E&R studies in Drosophila melanogaster have frequently resulted in inordinate numbers of candidate SNPs, particularly for complex traits. Here, we contrast the genomic signature of adaptation following ~60 generations in a novel hot environment for D. melanogaster and D. simulans. For D. simulans, the regions carrying putatively selected loci were far more distinct, and thus harbored fewer false positives, than those in D. melanogaster. We propose that species without segregating inversions and higher recombination rates, such as D. simulans, are better suited for E&R studies that aim to characterize the genetic variants underlying the adaptive response.

Original languageEnglish
Pages (from-to)2337-2343
Number of pages7
JournalG3: Genes, Genomes, Genetics
Issue number7
Publication statusPublished - 1 Jul 2017
Externally publishedYes


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