Dual Proton/Anion Binding Through Reciprocal Allostery in Platinum(II) Lantern-Shaped Cages

Reciprocal allosteric regulation, where binding
events influence each other simultaneously, is a key
target for supramolecular chemists designing biomimetic
systems. Platinum(II) lantern-shaped cages, formed from
a series of ligands bearing central protonatable sites
of varied basicity through rational tuning of the backbone, featured nuanced dual action host-guest chemistry.
This reveals the first example of reciprocal allostery
in a supramolecular system, between protonation and
anion binding. Switching studies were conducted using
acid/base and silver/chloride stimuli, with single and
multi-anion systems.