TY - JOUR
T1 - Dynamics of T Cell, Antigen-Presenting Cell, and Pathogen Interactions during Recall Responses in the Lymph Node
AU - Chtanova, Tatyana
AU - Han, Seong Ji
AU - Schaeffer, Marie
AU - van Dooren, Giel G.
AU - Herzmark, Paul
AU - Striepen, Boris
AU - Robey, Ellen A.
PY - 2009/8/21
Y1 - 2009/8/21
N2 - Memory T cells circulate through lymph nodes where they are poised to respond rapidly upon re-exposure to a pathogen; however, the dynamics of memory T cell, antigen-presenting cell, and pathogen interactions during recall responses are largely unknown. We used a mouse model of infection with the intracellular protozoan parasite, Toxoplasma gondii, in conjunction with two-photon microscopy, to address this question. After challenge, memory T cells migrated more rapidly than naive T cells, relocalized toward the subcapsular sinus (SCS) near invaded macrophages, and engaged in prolonged interactions with infected cells. Parasite invasion of T cells occurred by direct transfer of the parasite from the target cell into the T cell and corresponded to an antigen-specific increase in the rate of T cell invasion. Our results provide insight into cellular interactions during recall responses and suggest a mechanism of pathogen subversion of the immune response.
AB - Memory T cells circulate through lymph nodes where they are poised to respond rapidly upon re-exposure to a pathogen; however, the dynamics of memory T cell, antigen-presenting cell, and pathogen interactions during recall responses are largely unknown. We used a mouse model of infection with the intracellular protozoan parasite, Toxoplasma gondii, in conjunction with two-photon microscopy, to address this question. After challenge, memory T cells migrated more rapidly than naive T cells, relocalized toward the subcapsular sinus (SCS) near invaded macrophages, and engaged in prolonged interactions with infected cells. Parasite invasion of T cells occurred by direct transfer of the parasite from the target cell into the T cell and corresponded to an antigen-specific increase in the rate of T cell invasion. Our results provide insight into cellular interactions during recall responses and suggest a mechanism of pathogen subversion of the immune response.
KW - CELLIMMUNO
UR - http://www.scopus.com/inward/record.url?scp=68649115555&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2009.06.023
DO - 10.1016/j.immuni.2009.06.023
M3 - Article
SN - 1074-7613
VL - 31
SP - 342
EP - 355
JO - Immunity
JF - Immunity
IS - 2
ER -