Dynamics of T Cell, Antigen-Presenting Cell, and Pathogen Interactions during Recall Responses in the Lymph Node

Tatyana Chtanova, Seong Ji Han, Marie Schaeffer, Giel G. van Dooren, Paul Herzmark, Boris Striepen, Ellen A. Robey*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

127 Citations (Scopus)

Abstract

Memory T cells circulate through lymph nodes where they are poised to respond rapidly upon re-exposure to a pathogen; however, the dynamics of memory T cell, antigen-presenting cell, and pathogen interactions during recall responses are largely unknown. We used a mouse model of infection with the intracellular protozoan parasite, Toxoplasma gondii, in conjunction with two-photon microscopy, to address this question. After challenge, memory T cells migrated more rapidly than naive T cells, relocalized toward the subcapsular sinus (SCS) near invaded macrophages, and engaged in prolonged interactions with infected cells. Parasite invasion of T cells occurred by direct transfer of the parasite from the target cell into the T cell and corresponded to an antigen-specific increase in the rate of T cell invasion. Our results provide insight into cellular interactions during recall responses and suggest a mechanism of pathogen subversion of the immune response.

Original languageEnglish
Pages (from-to)342-355
Number of pages14
JournalImmunity
Volume31
Issue number2
DOIs
Publication statusPublished - 21 Aug 2009
Externally publishedYes

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