Dysregulation of immune homeostasis in autoimmune diseases

Vijay K. Kuchroo; Pamela S. Ohashi; R. Balfour Sartor; Carola G. Vinuesa

doi:10.1038/nm.2621

Dysregulation of immune homeostasis in autoimmune diseases

Vijay K. Kuchroo^*, Pamela S. Ohashi, R. Balfour Sartor, Carola G. Vinuesa

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

96 Citations (Scopus)

Abstract

Great strides have been made in our understanding of the pathogenesis of autoimmune diseases. Research has identified genetic associations, new functional subsets of effector and regulatory T cells and the gut microbiota as crucial environmental factors in regulating immune function. This commentary discusses recent advances in our understanding of genetic and environmental factors as well as the role of innate and adaptive immune responses in driving immune-mediated tissue injury.

Original language	English
Pages (from-to)	42-47
Number of pages	6
Journal	Nature Medicine
Volume	18
Issue number	1
DOIs	https://doi.org/10.1038/nm.2621
Publication status	Published - Jan 2012

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title = "Dysregulation of immune homeostasis in autoimmune diseases",

abstract = "Great strides have been made in our understanding of the pathogenesis of autoimmune diseases. Research has identified genetic associations, new functional subsets of effector and regulatory T cells and the gut microbiota as crucial environmental factors in regulating immune function. This commentary discusses recent advances in our understanding of genetic and environmental factors as well as the role of innate and adaptive immune responses in driving immune-mediated tissue injury.",

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AB - Great strides have been made in our understanding of the pathogenesis of autoimmune diseases. Research has identified genetic associations, new functional subsets of effector and regulatory T cells and the gut microbiota as crucial environmental factors in regulating immune function. This commentary discusses recent advances in our understanding of genetic and environmental factors as well as the role of innate and adaptive immune responses in driving immune-mediated tissue injury.

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Dysregulation of immune homeostasis in autoimmune diseases

Abstract

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