Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially

A. M. Hughes; R. M. Lucas; A. J. Mcmichael; T. Dwyer; M. P. Pender; I. van der Mei; B. V. Taylor; P. Valery; C. Chapman; A. Coulthard; K. Dear; T. J. Kilpatrick; D. Williams; A. L. Ponsonby

doi:10.1111/cei.12077

Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially

A. M. Hughes^*, R. M. Lucas, A. J. Mcmichael, T. Dwyer, M. P. Pender, I. van der Mei, B. V. Taylor, P. Valery, C. Chapman, A. Coulthard, K. Dear, T. J. Kilpatrick, D. Williams, A. L. Ponsonby

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Summary: The increasing prevalence of immune-related diseases, including multiple sclerosis, may be partly explained by reduced microbial burden during childhood. Within a multi-centre case-control study population, we examined: (i) the co-morbid immune diseases profile of adults with a first clinical diagnosis of central nervous system demyelination (FCD) and (ii) sibship structure in relation to an autoimmune (FCD) and an allergic (asthma) disease. FCD cases (n=282) were aged 18-59 years; controls (n=558) were matched on age, sex and region. Measures include: history of doctor-diagnosed asthma; sibling profile (number; dates of birth); and regular childcare attendance. FCD cases did not differ from controls with regard to personal or family history of allergy, but had a greater likelihood of chronic fatigue syndrome [odds ratio (OR)=3·11; 95% confidence interval (CI) 1·11, 8·71]. Having any younger siblings showed reduced odds of FCD (OR=0·68; 95% CI: 0·49, 0·95) but not asthma (OR=1·47; 95% CI: 0·91, 2·38). In contrast, an increasing number of older siblings was associated with reduced risk of asthma (P trend=0·04) but not FCD (P trend=0·66). Allergies were not over-represented among people presenting with FCD. Sibship characteristics influence both FCD and asthma risk but the underlying mechanisms differ, possibly due to the timing of the putative 'sibling effect'.

Original language	English
Pages (from-to)	466-474
Number of pages	9
Journal	Clinical and Experimental Immunology
Volume	172
Issue number	3
DOIs	https://doi.org/10.1111/cei.12077
Publication status	Published - Jun 2013

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Hughes, A. M., Lucas, R. M., Mcmichael, A. J., Dwyer, T., Pender, M. P., van der Mei, I., Taylor, B. V., Valery, P., Chapman, C., Coulthard, A., Dear, K., Kilpatrick, T. J., Williams, D., & Ponsonby, A. L. (2013). Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially. Clinical and Experimental Immunology, 172(3), 466-474. https://doi.org/10.1111/cei.12077

@article{213b77696abc4c89869f4f8ce8562a64,

title = "Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially",

abstract = "Summary: The increasing prevalence of immune-related diseases, including multiple sclerosis, may be partly explained by reduced microbial burden during childhood. Within a multi-centre case-control study population, we examined: (i) the co-morbid immune diseases profile of adults with a first clinical diagnosis of central nervous system demyelination (FCD) and (ii) sibship structure in relation to an autoimmune (FCD) and an allergic (asthma) disease. FCD cases (n=282) were aged 18-59 years; controls (n=558) were matched on age, sex and region. Measures include: history of doctor-diagnosed asthma; sibling profile (number; dates of birth); and regular childcare attendance. FCD cases did not differ from controls with regard to personal or family history of allergy, but had a greater likelihood of chronic fatigue syndrome [odds ratio (OR)=3·11; 95% confidence interval (CI) 1·11, 8·71]. Having any younger siblings showed reduced odds of FCD (OR=0·68; 95% CI: 0·49, 0·95) but not asthma (OR=1·47; 95% CI: 0·91, 2·38). In contrast, an increasing number of older siblings was associated with reduced risk of asthma (P trend=0·04) but not FCD (P trend=0·66). Allergies were not over-represented among people presenting with FCD. Sibship characteristics influence both FCD and asthma risk but the underlying mechanisms differ, possibly due to the timing of the putative 'sibling effect'.",

keywords = "Allergy, Asthma, Autoimmunity, Hygiene, Multiple sclerosis, Siblings",

author = "Hughes, {A. M.} and Lucas, {R. M.} and Mcmichael, {A. J.} and T. Dwyer and Pender, {M. P.} and {van der Mei}, I. and Taylor, {B. V.} and P. Valery and C. Chapman and A. Coulthard and K. Dear and Kilpatrick, {T. J.} and D. Williams and Ponsonby, {A. L.}",

year = "2013",

month = jun,

doi = "10.1111/cei.12077",

language = "English",

volume = "172",

pages = "466--474",

journal = "Clinical and Experimental Immunology",

issn = "0009-9104",

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Hughes, AM, Lucas, RM, Mcmichael, AJ, Dwyer, T, Pender, MP, van der Mei, I, Taylor, BV, Valery, P, Chapman, C, Coulthard, A, Dear, K, Kilpatrick, TJ, Williams, D & Ponsonby, AL 2013, 'Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially', Clinical and Experimental Immunology, vol. 172, no. 3, pp. 466-474. https://doi.org/10.1111/cei.12077

TY - JOUR

T1 - Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially

AU - Hughes, A. M.

AU - Lucas, R. M.

AU - Mcmichael, A. J.

AU - Dwyer, T.

AU - Pender, M. P.

AU - van der Mei, I.

AU - Taylor, B. V.

AU - Valery, P.

AU - Chapman, C.

AU - Coulthard, A.

AU - Dear, K.

AU - Kilpatrick, T. J.

AU - Williams, D.

AU - Ponsonby, A. L.

PY - 2013/6

Y1 - 2013/6

N2 - Summary: The increasing prevalence of immune-related diseases, including multiple sclerosis, may be partly explained by reduced microbial burden during childhood. Within a multi-centre case-control study population, we examined: (i) the co-morbid immune diseases profile of adults with a first clinical diagnosis of central nervous system demyelination (FCD) and (ii) sibship structure in relation to an autoimmune (FCD) and an allergic (asthma) disease. FCD cases (n=282) were aged 18-59 years; controls (n=558) were matched on age, sex and region. Measures include: history of doctor-diagnosed asthma; sibling profile (number; dates of birth); and regular childcare attendance. FCD cases did not differ from controls with regard to personal or family history of allergy, but had a greater likelihood of chronic fatigue syndrome [odds ratio (OR)=3·11; 95% confidence interval (CI) 1·11, 8·71]. Having any younger siblings showed reduced odds of FCD (OR=0·68; 95% CI: 0·49, 0·95) but not asthma (OR=1·47; 95% CI: 0·91, 2·38). In contrast, an increasing number of older siblings was associated with reduced risk of asthma (P trend=0·04) but not FCD (P trend=0·66). Allergies were not over-represented among people presenting with FCD. Sibship characteristics influence both FCD and asthma risk but the underlying mechanisms differ, possibly due to the timing of the putative 'sibling effect'.

AB - Summary: The increasing prevalence of immune-related diseases, including multiple sclerosis, may be partly explained by reduced microbial burden during childhood. Within a multi-centre case-control study population, we examined: (i) the co-morbid immune diseases profile of adults with a first clinical diagnosis of central nervous system demyelination (FCD) and (ii) sibship structure in relation to an autoimmune (FCD) and an allergic (asthma) disease. FCD cases (n=282) were aged 18-59 years; controls (n=558) were matched on age, sex and region. Measures include: history of doctor-diagnosed asthma; sibling profile (number; dates of birth); and regular childcare attendance. FCD cases did not differ from controls with regard to personal or family history of allergy, but had a greater likelihood of chronic fatigue syndrome [odds ratio (OR)=3·11; 95% confidence interval (CI) 1·11, 8·71]. Having any younger siblings showed reduced odds of FCD (OR=0·68; 95% CI: 0·49, 0·95) but not asthma (OR=1·47; 95% CI: 0·91, 2·38). In contrast, an increasing number of older siblings was associated with reduced risk of asthma (P trend=0·04) but not FCD (P trend=0·66). Allergies were not over-represented among people presenting with FCD. Sibship characteristics influence both FCD and asthma risk but the underlying mechanisms differ, possibly due to the timing of the putative 'sibling effect'.

KW - Allergy

KW - Asthma

KW - Autoimmunity

KW - Hygiene

KW - Multiple sclerosis

KW - Siblings

UR - http://www.scopus.com/inward/record.url?scp=84876725517&partnerID=8YFLogxK

U2 - 10.1111/cei.12077

DO - 10.1111/cei.12077

M3 - Article

SN - 0009-9104

VL - 172

SP - 466

EP - 474

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 3

ER -

Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially

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