Editorial: Get Over the Gut: Apicomplexan Parasite Interaction, Survival and Stage Progression in Vertebrate and Invertebrate Digestive Tracts

Nicholas C. Smith, Robert E. Sinden, Chandra Ramakrishnan*

*Corresponding author for this work

    Research output: Contribution to journalEditorialpeer-review

    4 Citations (Scopus)

    Abstract

    For endoparasites, invasion of their hosts represents the greatest challenge to survival; for many it is the gut of the host/vector that present this barrier. Those barriers are increasingly being recognized as optimal targets for intervention strategies (Sinden, 2010; Smith et al., 2014; Sinden, 2017). The phylum Apicomplexa embraces thousands of species of parasites of vertebrates and invertebrates, many of major veterinary/medical importance including important agents of zoonoses. Whilst certain parasites are monoxenous (e.g., Eimeria, Cryptosporidium), others are heteroxenous (e.g. Plasmodium, Toxoplasma gondii) with distinct developmental pathways in each host. All Apicomplexans are thought to undergo critical developmental phases within intestinal tracts; thus, infection or transition of a gut is crucial for their survival. In this Research Topic, we present contributions on mechanisms of gut infection and traversal; the gut as a barrier to parasites; model systems for parasite development, and the impact of gut microbiota upon the infection process.
    Original languageEnglish
    Article number680555
    JournalFrontiers in Cellular and Infection Microbiology
    Volume11
    DOIs
    Publication statusPublished - 28 Apr 2021

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