TY - JOUR
T1 - Editorial
T2 - Get Over the Gut: Apicomplexan Parasite Interaction, Survival and Stage Progression in Vertebrate and Invertebrate Digestive Tracts
AU - Smith, Nicholas C.
AU - Sinden, Robert E.
AU - Ramakrishnan, Chandra
PY - 2021/4/28
Y1 - 2021/4/28
N2 - For endoparasites, invasion of their hosts represents the greatest challenge to survival; for many it is the gut of the host/vector that present this barrier. Those barriers are increasingly being recognized as optimal targets for intervention strategies (Sinden, 2010; Smith et al., 2014; Sinden, 2017). The phylum Apicomplexa embraces thousands of species of parasites of vertebrates and invertebrates, many of major veterinary/medical importance including important agents of zoonoses. Whilst certain parasites are monoxenous (e.g., Eimeria, Cryptosporidium), others are heteroxenous (e.g. Plasmodium, Toxoplasma gondii) with distinct developmental pathways in each host. All Apicomplexans are thought to undergo critical developmental phases within intestinal tracts; thus, infection or transition of a gut is crucial for their survival. In this Research Topic, we present contributions on mechanisms of gut infection and traversal; the gut as a barrier to parasites; model systems for parasite development, and the impact of gut microbiota upon the infection process.
AB - For endoparasites, invasion of their hosts represents the greatest challenge to survival; for many it is the gut of the host/vector that present this barrier. Those barriers are increasingly being recognized as optimal targets for intervention strategies (Sinden, 2010; Smith et al., 2014; Sinden, 2017). The phylum Apicomplexa embraces thousands of species of parasites of vertebrates and invertebrates, many of major veterinary/medical importance including important agents of zoonoses. Whilst certain parasites are monoxenous (e.g., Eimeria, Cryptosporidium), others are heteroxenous (e.g. Plasmodium, Toxoplasma gondii) with distinct developmental pathways in each host. All Apicomplexans are thought to undergo critical developmental phases within intestinal tracts; thus, infection or transition of a gut is crucial for their survival. In this Research Topic, we present contributions on mechanisms of gut infection and traversal; the gut as a barrier to parasites; model systems for parasite development, and the impact of gut microbiota upon the infection process.
KW - Apicomplexa
KW - barrier
KW - gut
KW - host
KW - immune system
KW - microbiota
KW - model system
UR - http://www.scopus.com/inward/record.url?scp=85105959366&partnerID=8YFLogxK
U2 - 10.3389/fcimb.2021.680555
DO - 10.3389/fcimb.2021.680555
M3 - Editorial
SN - 2235-2988
VL - 11
JO - Frontiers in Cellular and Infection Microbiology
JF - Frontiers in Cellular and Infection Microbiology
M1 - 680555
ER -