Effects of cerebrovascular risk factors on gray matter volume in adults aged 60-64 years: A voxel-based morphometric study

Xiaohua Chen*, Wei Wen, Kaarin J. Anstey, Perminder S. Sachdev

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    The effect of putative cerebrovascular risk factors on gray matter volume in a community-dwelling, non-demented 60- to 64-year-old cohort was investigated. Cranial T1-weighted MRI scans were obtained in 337 adults and voxel-based morphometric analyses were applied to detect regional gray matter volume differences related to hypertension, diabetes, smoking, and hyperlipidemia in men and women, respectively. Hypertension-related gray matter volume reduction was found in right superior, bilateral medial frontal, left superior temporal and left precentral gyri in men. No regional differences in gray matter related to hypertension were seen in women. Conversely, female but not male smokers had more gray matter volume in right fusiform gyrus and right temporal subgyral gray matter. No differences were observed in gray matter volume in association with diabetes or hyperlipidemia for men or women. Our results suggest that there are different patterns of regional effects in gray matter volume in relation to different cerebrovascular risk factors, and sex differences for the same risk factors.

    Original languageEnglish
    Pages (from-to)105-114
    Number of pages10
    JournalPsychiatry Research - Neuroimaging
    Volume147
    Issue number2-3
    DOIs
    Publication statusPublished - 30 Oct 2006

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