Electrophysiological studies of malaria parasite-infected erythrocytes: Current status

Henry M. Staines; Abdulnaser Alkhalil; Richard J. Allen; Hugo R. De Jonge; Elvira Derbyshire; Stéphane Egée; Hagai Ginsburg; David A. Hill; Stephan M. Huber; Kiaran Kirk; Florian Lang; Godfrey Lisk; Eugene Oteng; Ajay D. Pillai; Kempaiah Rayavara; Sherin Rouhani; Kevin J. Saliba; Crystal Shen; Tsione Solomon; Serge L.Y. Thomas; Patrick Verloo; Sanjay A. Desai

doi:10.1016/j.ijpara.2006.12.013

Electrophysiological studies of malaria parasite-infected erythrocytes: Current status

Henry M. Staines^*, Abdulnaser Alkhalil, Richard J. Allen, Hugo R. De Jonge, Elvira Derbyshire, Stéphane Egée, Hagai Ginsburg, David A. Hill, Stephan M. Huber, Kiaran Kirk, Florian Lang, Godfrey Lisk, Eugene Oteng, Ajay D. Pillai, Kempaiah Rayavara, Sherin Rouhani, Kevin J. Saliba, Crystal Shen, Tsione Solomon, Serge L.Y. ThomasPatrick Verloo, Sanjay A. Desai

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

90 Citations (Scopus)

Abstract

The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding.

Original language	English
Pages (from-to)	475-482
Number of pages	8
Journal	International Journal for Parasitology
Volume	37
Issue number	5
DOIs	https://doi.org/10.1016/j.ijpara.2006.12.013
Publication status	Published - Apr 2007

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10.1016/j.ijpara.2006.12.013

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Staines, H. M., Alkhalil, A., Allen, R. J., De Jonge, H. R., Derbyshire, E., Egée, S., Ginsburg, H., Hill, D. A., Huber, S. M., Kirk, K., Lang, F., Lisk, G., Oteng, E., Pillai, A. D., Rayavara, K., Rouhani, S., Saliba, K. J., Shen, C., Solomon, T., ... Desai, S. A. (2007). Electrophysiological studies of malaria parasite-infected erythrocytes: Current status. International Journal for Parasitology, 37(5), 475-482. https://doi.org/10.1016/j.ijpara.2006.12.013

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title = "Electrophysiological studies of malaria parasite-infected erythrocytes: Current status",

abstract = "The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding.",

keywords = "Ion channels, New permeability pathways, Oxidation, PSAC, Patch-clamp, Plasmodium",

author = "Staines, {Henry M.} and Abdulnaser Alkhalil and Allen, {Richard J.} and {De Jonge}, {Hugo R.} and Elvira Derbyshire and St{\'e}phane Eg{\'e}e and Hagai Ginsburg and Hill, {David A.} and Huber, {Stephan M.} and Kiaran Kirk and Florian Lang and Godfrey Lisk and Eugene Oteng and Pillai, {Ajay D.} and Kempaiah Rayavara and Sherin Rouhani and Saliba, {Kevin J.} and Crystal Shen and Tsione Solomon and Thomas, {Serge L.Y.} and Patrick Verloo and Desai, {Sanjay A.}",

year = "2007",

month = apr,

doi = "10.1016/j.ijpara.2006.12.013",

language = "English",

volume = "37",

pages = "475--482",

journal = "International Journal for Parasitology",

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Staines, HM, Alkhalil, A, Allen, RJ, De Jonge, HR, Derbyshire, E, Egée, S, Ginsburg, H, Hill, DA, Huber, SM, Kirk, K, Lang, F, Lisk, G, Oteng, E, Pillai, AD, Rayavara, K, Rouhani, S, Saliba, KJ, Shen, C, Solomon, T, Thomas, SLY, Verloo, P & Desai, SA 2007, 'Electrophysiological studies of malaria parasite-infected erythrocytes: Current status', International Journal for Parasitology, vol. 37, no. 5, pp. 475-482. https://doi.org/10.1016/j.ijpara.2006.12.013

TY - JOUR

T1 - Electrophysiological studies of malaria parasite-infected erythrocytes

T2 - Current status

AU - Staines, Henry M.

AU - Alkhalil, Abdulnaser

AU - Allen, Richard J.

AU - De Jonge, Hugo R.

AU - Derbyshire, Elvira

AU - Egée, Stéphane

AU - Ginsburg, Hagai

AU - Hill, David A.

AU - Huber, Stephan M.

AU - Kirk, Kiaran

AU - Lang, Florian

AU - Lisk, Godfrey

AU - Oteng, Eugene

AU - Pillai, Ajay D.

AU - Rayavara, Kempaiah

AU - Rouhani, Sherin

AU - Saliba, Kevin J.

AU - Shen, Crystal

AU - Solomon, Tsione

AU - Thomas, Serge L.Y.

AU - Verloo, Patrick

AU - Desai, Sanjay A.

PY - 2007/4

Y1 - 2007/4

N2 - The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding.

AB - The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding.

KW - Ion channels

KW - New permeability pathways

KW - Oxidation

KW - PSAC

KW - Patch-clamp

KW - Plasmodium

UR - http://www.scopus.com/inward/record.url?scp=33947158084&partnerID=8YFLogxK

U2 - 10.1016/j.ijpara.2006.12.013

DO - 10.1016/j.ijpara.2006.12.013

M3 - Review article

SN - 0020-7519

VL - 37

SP - 475

EP - 482

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 5

ER -

Electrophysiological studies of malaria parasite-infected erythrocytes: Current status

Abstract

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