Emergence of Kaposi's sarcoma herpesvirus-associated complications following corticosteroid use in TB-IRIS

Maura Manion; Thomas Uldrick; Mark N. Polizzotto; Virginia Sheikh; Gregg Roby; Kathryn Lurain; Dorinda Metzger; Jo Ann M. Mican; Alice Pau; Andrea Lisco; Elizabeth Laidlaw; Dima A. Hammoud; Denise Whitby; Robert Yarchoan; Irini Sereti

doi:10.1093/ofid/ofy217

Emergence of Kaposi's sarcoma herpesvirus-associated complications following corticosteroid use in TB-IRIS

Maura Manion^*, Thomas Uldrick, Mark N. Polizzotto, Virginia Sheikh, Gregg Roby, Kathryn Lurain, Dorinda Metzger, Jo Ann M. Mican, Alice Pau, Andrea Lisco, Elizabeth Laidlaw, Dima A. Hammoud, Denise Whitby, Robert Yarchoan, Irini Sereti

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Corticosteroid use was associated with development of Kaposi's sarcoma or multicentric Castleman disease in 3 patients with mycobacterial immune reconstitution inflammatory syndrome (IRIS) treated with corticosteroids. Monitoring for development of Kaposi's sarcoma and alternative treatment may be beneficial for patients with IRIS, especially in the presence of preexisting co-infection with Kaposi's sarcoma-associated herpesvirus.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofy217
Publication status	Published - 1 Oct 2018
Externally published	Yes

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10.1093/ofid/ofy217

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Manion, M., Uldrick, T., Polizzotto, M. N., Sheikh, V., Roby, G., Lurain, K., Metzger, D., Mican, J. A. M., Pau, A., Lisco, A., Laidlaw, E., Hammoud, D. A., Whitby, D., Yarchoan, R., & Sereti, I. (2018). Emergence of Kaposi's sarcoma herpesvirus-associated complications following corticosteroid use in TB-IRIS. Open Forum Infectious Diseases, 5(10). https://doi.org/10.1093/ofid/ofy217

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abstract = "Corticosteroid use was associated with development of Kaposi's sarcoma or multicentric Castleman disease in 3 patients with mycobacterial immune reconstitution inflammatory syndrome (IRIS) treated with corticosteroids. Monitoring for development of Kaposi's sarcoma and alternative treatment may be beneficial for patients with IRIS, especially in the presence of preexisting co-infection with Kaposi's sarcoma-associated herpesvirus.",

keywords = "KSHV, TB-IRIS",

author = "Maura Manion and Thomas Uldrick and Polizzotto, {Mark N.} and Virginia Sheikh and Gregg Roby and Kathryn Lurain and Dorinda Metzger and Mican, {Jo Ann M.} and Alice Pau and Andrea Lisco and Elizabeth Laidlaw and Hammoud, {Dima A.} and Denise Whitby and Robert Yarchoan and Irini Sereti",

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Manion, M, Uldrick, T, Polizzotto, MN, Sheikh, V, Roby, G, Lurain, K, Metzger, D, Mican, JAM, Pau, A, Lisco, A, Laidlaw, E, Hammoud, DA, Whitby, D, Yarchoan, R & Sereti, I 2018, 'Emergence of Kaposi's sarcoma herpesvirus-associated complications following corticosteroid use in TB-IRIS', Open Forum Infectious Diseases, vol. 5, no. 10. https://doi.org/10.1093/ofid/ofy217

TY - JOUR

T1 - Emergence of Kaposi's sarcoma herpesvirus-associated complications following corticosteroid use in TB-IRIS

AU - Manion, Maura

AU - Uldrick, Thomas

AU - Polizzotto, Mark N.

AU - Sheikh, Virginia

AU - Roby, Gregg

AU - Lurain, Kathryn

AU - Metzger, Dorinda

AU - Mican, Jo Ann M.

AU - Pau, Alice

AU - Lisco, Andrea

AU - Laidlaw, Elizabeth

AU - Hammoud, Dima A.

AU - Whitby, Denise

AU - Yarchoan, Robert

AU - Sereti, Irini

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Corticosteroid use was associated with development of Kaposi's sarcoma or multicentric Castleman disease in 3 patients with mycobacterial immune reconstitution inflammatory syndrome (IRIS) treated with corticosteroids. Monitoring for development of Kaposi's sarcoma and alternative treatment may be beneficial for patients with IRIS, especially in the presence of preexisting co-infection with Kaposi's sarcoma-associated herpesvirus.

AB - Corticosteroid use was associated with development of Kaposi's sarcoma or multicentric Castleman disease in 3 patients with mycobacterial immune reconstitution inflammatory syndrome (IRIS) treated with corticosteroids. Monitoring for development of Kaposi's sarcoma and alternative treatment may be beneficial for patients with IRIS, especially in the presence of preexisting co-infection with Kaposi's sarcoma-associated herpesvirus.

KW - KSHV

KW - TB-IRIS

UR - http://www.scopus.com/inward/record.url?scp=85068027224&partnerID=8YFLogxK

U2 - 10.1093/ofid/ofy217

DO - 10.1093/ofid/ofy217

M3 - Article

SN - 2328-8957

VL - 5

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 10

ER -

Emergence of Kaposi's sarcoma herpesvirus-associated complications following corticosteroid use in TB-IRIS

Abstract

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