Employment of microRNA profiles and RNA interference and antagomirs for the characterization and treatment of respiratory disease

Ming Yang; Joerg Mattes; Philip M. Hansbro; Paul S. Foster

doi:10.1016/j.ddstr.2006.10.001

Employment of microRNA profiles and RNA interference and antagomirs for the characterization and treatment of respiratory disease

Ming Yang^*, Joerg Mattes, Philip M. Hansbro, Paul S. Foster

^*Corresponding author for this work

John Curtin School of Medical Research

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

The complex etiology and heterogeneity of respiratory diseases have made it difficult to design pharmacological reagents that show good efficacy across a diseased population. The discovery of small 'non-coding' RNA molecules (small interfering (si)- and micro-RNAs) that regulate the function of a gene or clusters of genes and the design of synthetic analogues of these molecules may provide new directions for the treatment and characterization of respiratory disorders.

Original language	English
Pages (from-to)	325-332
Number of pages	8
Journal	Drug Discovery Today: Therapeutic Strategies
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/j.ddstr.2006.10.001
Publication status	Published - 2006

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10.1016/j.ddstr.2006.10.001

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title = "Employment of microRNA profiles and RNA interference and antagomirs for the characterization and treatment of respiratory disease",

abstract = "The complex etiology and heterogeneity of respiratory diseases have made it difficult to design pharmacological reagents that show good efficacy across a diseased population. The discovery of small 'non-coding' RNA molecules (small interfering (si)- and micro-RNAs) that regulate the function of a gene or clusters of genes and the design of synthetic analogues of these molecules may provide new directions for the treatment and characterization of respiratory disorders.",

author = "Ming Yang and Joerg Mattes and Hansbro, {Philip M.} and Foster, {Paul S.}",

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AU - Yang, Ming

AU - Mattes, Joerg

AU - Hansbro, Philip M.

AU - Foster, Paul S.

PY - 2006

Y1 - 2006

N2 - The complex etiology and heterogeneity of respiratory diseases have made it difficult to design pharmacological reagents that show good efficacy across a diseased population. The discovery of small 'non-coding' RNA molecules (small interfering (si)- and micro-RNAs) that regulate the function of a gene or clusters of genes and the design of synthetic analogues of these molecules may provide new directions for the treatment and characterization of respiratory disorders.

AB - The complex etiology and heterogeneity of respiratory diseases have made it difficult to design pharmacological reagents that show good efficacy across a diseased population. The discovery of small 'non-coding' RNA molecules (small interfering (si)- and micro-RNAs) that regulate the function of a gene or clusters of genes and the design of synthetic analogues of these molecules may provide new directions for the treatment and characterization of respiratory disorders.

UR - http://www.scopus.com/inward/record.url?scp=33751285540&partnerID=8YFLogxK

U2 - 10.1016/j.ddstr.2006.10.001

DO - 10.1016/j.ddstr.2006.10.001

M3 - Review article

SN - 1740-6773

VL - 3

SP - 325

EP - 332

JO - Drug Discovery Today: Therapeutic Strategies

JF - Drug Discovery Today: Therapeutic Strategies

IS - 3

ER -

Employment of microRNA profiles and RNA interference and antagomirs for the characterization and treatment of respiratory disease

Abstract

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