Enantioselective total syntheses of the alkaloids (-)-rhazinal, (-)-rhazinilam, (-)-leuconolam and (+)-epi-leuconolam

Martin G. Banwell*, Daniel A.S. Beck, Anthony C. Willis

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)

    Abstract

    The title alkaloids, (-)-1, (-)-2, (-)-4 and (+)-5 respectively, have each been prepared from the enantiomerically enriched (74% ee) tetrahydroindolizine 14 which is itself obtained via an organocatalyzed and enantioselective intramolecular Michael addition reaction of the pyrrole 13 incorporating an N-tethered and β,β-disubstituted acrylaldehyde moiety.

    Original languageEnglish
    Pages (from-to)163-174
    Number of pages12
    JournalArkivoc
    Volume2006
    Issue number3
    Publication statusPublished - 10 Sept 2005

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