TY - JOUR
T1 - Endogenous endophthalmitis
T2 - 10-year experience at a tertiary referral centre
AU - Connell, P. P.
AU - O'Neill, E. C.
AU - Fabinyi, D.
AU - Islam, F. M.A.
AU - Buttery, R.
AU - McCombe, M.
AU - Essex, R. W.
AU - Roufail, E.
AU - Clark, B.
AU - Chiu, D.
AU - Campbell, W.
AU - Allen, P.
PY - 2011/1
Y1 - 2011/1
N2 - Purpose Endogenous endophthalmitis (EE) is a sight-threatening emergency and the aetiology is often multifactorial. Delayed diagnosis may exacerbate the poor visual prognosis. We describe the management and visual outcomes of EE presenting to a tertiary referral centre.Patients and Methods A prospective consecutive case series of 64 patients presenting with presumed EE from 1997 to 2007 to the Royal Victorian Eye and Ear Hospital were included. All data were collected in a standardized manner. Outcome measures included: visual acuity, microbial profiles, and vitrectomy rate. Results In total, 64 cases of EE were identified over the study period with a mean age of 57.5 years, and 53.5% were male. Presenting acuities ranged from Snellen 6/6 to no perception of light (NPL). Identifiable risk factors were present in 78.1%, with the majority related to intravenous drug abuse. A 64.1% culture positivity rate was recorded. A vitrectomy rate of 57, 56, and 21% was recorded in documented bacterial, fungal, and no growth cases, respectively. Final Snellen acuities ranged from 6/6 to NPL. A total of 5 out of 64 eyes were enucleated, of which 3 identified Klebsiellaspecies. Better visual outcome was documented in fungal cases. Conclusion EE is a serious ocular condition and has a varied aetiology. Visual outcomes are often poor, irrespective of the method of management. Fungal aetiology often confers a better prognosis, and vitrectomy is advocated for bacterial proven cases. & 2011 Macmillan Publishers Limited. All rights reserved.
AB - Purpose Endogenous endophthalmitis (EE) is a sight-threatening emergency and the aetiology is often multifactorial. Delayed diagnosis may exacerbate the poor visual prognosis. We describe the management and visual outcomes of EE presenting to a tertiary referral centre.Patients and Methods A prospective consecutive case series of 64 patients presenting with presumed EE from 1997 to 2007 to the Royal Victorian Eye and Ear Hospital were included. All data were collected in a standardized manner. Outcome measures included: visual acuity, microbial profiles, and vitrectomy rate. Results In total, 64 cases of EE were identified over the study period with a mean age of 57.5 years, and 53.5% were male. Presenting acuities ranged from Snellen 6/6 to no perception of light (NPL). Identifiable risk factors were present in 78.1%, with the majority related to intravenous drug abuse. A 64.1% culture positivity rate was recorded. A vitrectomy rate of 57, 56, and 21% was recorded in documented bacterial, fungal, and no growth cases, respectively. Final Snellen acuities ranged from 6/6 to NPL. A total of 5 out of 64 eyes were enucleated, of which 3 identified Klebsiellaspecies. Better visual outcome was documented in fungal cases. Conclusion EE is a serious ocular condition and has a varied aetiology. Visual outcomes are often poor, irrespective of the method of management. Fungal aetiology often confers a better prognosis, and vitrectomy is advocated for bacterial proven cases. & 2011 Macmillan Publishers Limited. All rights reserved.
KW - drug abuse
KW - endogenous endophthalmitis
KW - microbiology
KW - risk factors
KW - visual acuity
UR - http://www.scopus.com/inward/record.url?scp=78651352558&partnerID=8YFLogxK
U2 - 10.1038/eye.2010.145
DO - 10.1038/eye.2010.145
M3 - Article
SN - 0950-222X
VL - 25
SP - 66
EP - 72
JO - Eye
JF - Eye
IS - 1
ER -