Engineering of chitosan-hydroxyapatite-magnetite hierarchical scaffolds for guided bone growth

Alessandro Pistone; Daniela Iannazzo; Consuelo Celesti; Elpida Piperopoulos; Deepu Ashok; Arianna Cembran; Antonio Tricoli; David Nisbet

doi:10.3390/ma12142321

Engineering of chitosan-hydroxyapatite-magnetite hierarchical scaffolds for guided bone growth

Alessandro Pistone^*, Daniela Iannazzo, Consuelo Celesti, Elpida Piperopoulos, Deepu Ashok, Arianna Cembran, Antonio Tricoli, David Nisbet

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Bioabsorbable materials have received increasing attention as innovative systems for the development of osteoconductive biomaterials for bone tissue engineering. In this paper, chitosan-based composites were synthesized adding hydroxyapatite and/or magnetite in a chitosan matrix by in situ precipitation technique. Composites were characterized by optical and electron microscopy, thermogravimetric analyses (TGA), x-ray diffraction (XRD), and in vitro cell culture studies. Hydroxyapatite and magnetite were found to be homogeneously dispersed in the chitosan matrix and the composites showed superior biocompatibility and the ability to support cell attachment and proliferation; in particular, the chitosan/hydroxyapatite/magnetite composite (CS/HA/MGN) demonstrated superior bioactivity with respect to pure chitosan (CS) and to the chitosan/hydroxyapatite (CS/HA) scaffolds.

Original language	English
Article number	2321
Journal	Materials
Volume	12
Issue number	14
DOIs	https://doi.org/10.3390/ma12142321
Publication status	Published - 1 Jul 2019

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title = "Engineering of chitosan-hydroxyapatite-magnetite hierarchical scaffolds for guided bone growth",

abstract = "Bioabsorbable materials have received increasing attention as innovative systems for the development of osteoconductive biomaterials for bone tissue engineering. In this paper, chitosan-based composites were synthesized adding hydroxyapatite and/or magnetite in a chitosan matrix by in situ precipitation technique. Composites were characterized by optical and electron microscopy, thermogravimetric analyses (TGA), x-ray diffraction (XRD), and in vitro cell culture studies. Hydroxyapatite and magnetite were found to be homogeneously dispersed in the chitosan matrix and the composites showed superior biocompatibility and the ability to support cell attachment and proliferation; in particular, the chitosan/hydroxyapatite/magnetite composite (CS/HA/MGN) demonstrated superior bioactivity with respect to pure chitosan (CS) and to the chitosan/hydroxyapatite (CS/HA) scaffolds.",

keywords = "Chitosan/hydroxyapatite, Magnetite, Osteoconduction, Tissue engineering",

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AU - Pistone, Alessandro

AU - Iannazzo, Daniela

AU - Celesti, Consuelo

AU - Piperopoulos, Elpida

AU - Ashok, Deepu

AU - Cembran, Arianna

AU - Tricoli, Antonio

AU - Nisbet, David

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Bioabsorbable materials have received increasing attention as innovative systems for the development of osteoconductive biomaterials for bone tissue engineering. In this paper, chitosan-based composites were synthesized adding hydroxyapatite and/or magnetite in a chitosan matrix by in situ precipitation technique. Composites were characterized by optical and electron microscopy, thermogravimetric analyses (TGA), x-ray diffraction (XRD), and in vitro cell culture studies. Hydroxyapatite and magnetite were found to be homogeneously dispersed in the chitosan matrix and the composites showed superior biocompatibility and the ability to support cell attachment and proliferation; in particular, the chitosan/hydroxyapatite/magnetite composite (CS/HA/MGN) demonstrated superior bioactivity with respect to pure chitosan (CS) and to the chitosan/hydroxyapatite (CS/HA) scaffolds.

AB - Bioabsorbable materials have received increasing attention as innovative systems for the development of osteoconductive biomaterials for bone tissue engineering. In this paper, chitosan-based composites were synthesized adding hydroxyapatite and/or magnetite in a chitosan matrix by in situ precipitation technique. Composites were characterized by optical and electron microscopy, thermogravimetric analyses (TGA), x-ray diffraction (XRD), and in vitro cell culture studies. Hydroxyapatite and magnetite were found to be homogeneously dispersed in the chitosan matrix and the composites showed superior biocompatibility and the ability to support cell attachment and proliferation; in particular, the chitosan/hydroxyapatite/magnetite composite (CS/HA/MGN) demonstrated superior bioactivity with respect to pure chitosan (CS) and to the chitosan/hydroxyapatite (CS/HA) scaffolds.

KW - Chitosan/hydroxyapatite

KW - Magnetite

KW - Osteoconduction

KW - Tissue engineering

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ER -

Engineering of chitosan-hydroxyapatite-magnetite hierarchical scaffolds for guided bone growth

Abstract

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