Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Vipul Agarwal; Priyanka Toshniwal; Natalie Smith; Nicole M. Smith; Binbin Li; Tristan D. Clemons; Lindsay T. Byrne; Foteini Kakulas; Fiona M. Wood; Mark Fear; Ben Corry; Swaminathan Iyer

doi:10.1039/c5cc06826f

Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Vipul Agarwal
, Priyanka Toshniwal
, Natalie Smith
, Nicole M. Smith
, Binbin Li
, Tristan D. Clemons
, Lindsay T. Byrne
, Foteini Kakulas
, Fiona M. Wood
, Mark Fear
, Ben Corry
, Swaminathan Iyer

Research output: Contribution to journal › Article › peer-review

Abstract

Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFb1 mediated upregulation of profibrotic marker, collagen I.

Original language	English
Pages (from-to)	327-330
Journal	Chemical Communications
Volume	52
Issue number	2
DOIs	https://doi.org/10.1039/c5cc06826f
Publication status	Published - 2016

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@article{511ae4f842d741ad9a1402c5087275c6,

title = "Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery",

abstract = "Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFb1 mediated upregulation of profibrotic marker, collagen I.",

author = "Vipul Agarwal and Priyanka Toshniwal and Natalie Smith and Smith, \{Nicole M.\} and Binbin Li and Clemons, \{Tristan D.\} and Byrne, \{Lindsay T.\} and Foteini Kakulas and Wood, \{Fiona M.\} and Mark Fear and Ben Corry and Swaminathan Iyer",

year = "2016",

doi = "10.1039/c5cc06826f",

language = "English",

volume = "52",

pages = "327--330",

journal = "Chemical Communications",

publisher = "Royal Society of Chemistry",

number = "2",

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T1 - Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

AU - Agarwal, Vipul

AU - Toshniwal, Priyanka

AU - Smith, Natalie

AU - Smith, Nicole M.

AU - Li, Binbin

AU - Clemons, Tristan D.

AU - Byrne, Lindsay T.

AU - Kakulas, Foteini

AU - Wood, Fiona M.

AU - Fear, Mark

AU - Corry, Ben

AU - Iyer, Swaminathan

PY - 2016

Y1 - 2016

N2 - Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFb1 mediated upregulation of profibrotic marker, collagen I.

AB - Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFb1 mediated upregulation of profibrotic marker, collagen I.

U2 - 10.1039/c5cc06826f

DO - 10.1039/c5cc06826f

M3 - Article

VL - 52

SP - 327

EP - 330

JO - Chemical Communications

JF - Chemical Communications

IS - 2

ER -

Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Abstract

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