Enzyme dynamics and engineering: One step at a time

Nobuhiko Tokuriki; Colin J. Jackson

doi:10.1016/j.chembiol.2014.10.003

Enzyme dynamics and engineering: One step at a time

Nobuhiko Tokuriki, Colin J. Jackson^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

7 Citations (Scopus)

Abstract

Although protein dynamics are accepted as being essential for enzyme function, their effects are not fully understood. In this issue of Chemistry and Biology, Gobeil and coworkers describe how engineered changes in the millisecond motions of a mutant TEM-1 β-lactamase do not significantly affect substrate turnover. This mutational robustness has implications for protein engineering and design strategies.

Original language	English
Pages (from-to)	1259-1260
Number of pages	2
Journal	Chemistry and Biology
Volume	21
Issue number	10
DOIs	https://doi.org/10.1016/j.chembiol.2014.10.003
Publication status	Published - 23 Oct 2014

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10.1016/j.chembiol.2014.10.003

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title = "Enzyme dynamics and engineering: One step at a time",

abstract = "Although protein dynamics are accepted as being essential for enzyme function, their effects are not fully understood. In this issue of Chemistry and Biology, Gobeil and coworkers describe how engineered changes in the millisecond motions of a mutant TEM-1 β-lactamase do not significantly affect substrate turnover. This mutational robustness has implications for protein engineering and design strategies.",

author = "Nobuhiko Tokuriki and Jackson, {Colin J.}",

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AU - Jackson, Colin J.

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AB - Although protein dynamics are accepted as being essential for enzyme function, their effects are not fully understood. In this issue of Chemistry and Biology, Gobeil and coworkers describe how engineered changes in the millisecond motions of a mutant TEM-1 β-lactamase do not significantly affect substrate turnover. This mutational robustness has implications for protein engineering and design strategies.

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U2 - 10.1016/j.chembiol.2014.10.003

DO - 10.1016/j.chembiol.2014.10.003

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SN - 1074-5521

VL - 21

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EP - 1260

JO - Chemistry and Biology

JF - Chemistry and Biology

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ER -

Enzyme dynamics and engineering: One step at a time

Abstract

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