Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

Wai Hong Tham; Julie Healer; Alan F. Cowman

doi:10.1016/j.pt.2011.10.002

Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

Wai Hong Tham, Julie Healer, Alan F. Cowman^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

139 Citations (Scopus)

Abstract

The global agenda for malaria eradication would benefit from development of a highly efficacious vaccine that protects against disease and interrupts transmission of Plasmodium falciparum. It is likely that such a vaccine will be multi-component, with antigens from different stages of the parasite life cycle. In this review, inclusion of blood stage antigens in such a vaccine is discussed. Erythrocyte binding-like (EBL) and P. falciparum reticulocyte binding-like (PfRh) proteins are reviewed with respect to their function in erythrocyte invasion, their role in eliciting antibodies contributing to protective immunity and reduction of invasion, leading subsequently to inhibition of parasite multiplication.

Original language	English
Pages (from-to)	23-30
Number of pages	8
Journal	Trends in Parasitology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.pt.2011.10.002
Publication status	Published - Jan 2012
Externally published	Yes

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10.1016/j.pt.2011.10.002

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AB - The global agenda for malaria eradication would benefit from development of a highly efficacious vaccine that protects against disease and interrupts transmission of Plasmodium falciparum. It is likely that such a vaccine will be multi-component, with antigens from different stages of the parasite life cycle. In this review, inclusion of blood stage antigens in such a vaccine is discussed. Erythrocyte binding-like (EBL) and P. falciparum reticulocyte binding-like (PfRh) proteins are reviewed with respect to their function in erythrocyte invasion, their role in eliciting antibodies contributing to protective immunity and reduction of invasion, leading subsequently to inhibition of parasite multiplication.

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Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

Abstract

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