Escherichia coli glucuronylsynthase: An engineered enzyme for the synthesis of β-glucuronides

Shane M. Wilkinson; Chu W. Liew; Joel P. Mackay; Hamzah M. Salleh; Stephen G. Withers; Malcolm D. McLeod

doi:10.1021/ol8002767

Escherichia coli glucuronylsynthase: An engineered enzyme for the synthesis of β-glucuronides

Shane M. Wilkinson, Chu W. Liew, Joel P. Mackay, Hamzah M. Salleh, Stephen G. Withers, Malcolm D. McLeod

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions.

Original language	English
Pages (from-to)	1585-1588
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	8
DOIs	https://doi.org/10.1021/ol8002767
Publication status	Published - 17 Apr 2008

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10.1021/ol8002767

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title = "Escherichia coli glucuronylsynthase: An engineered enzyme for the synthesis of β-glucuronides",

abstract = "The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions.",

author = "Wilkinson, \{Shane M.\} and Liew, \{Chu W.\} and Mackay, \{Joel P.\} and Salleh, \{Hamzah M.\} and Withers, \{Stephen G.\} and McLeod, \{Malcolm D.\}",

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journal = "Organic Letters",

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T1 - Escherichia coli glucuronylsynthase

T2 - An engineered enzyme for the synthesis of β-glucuronides

AU - Wilkinson, Shane M.

AU - Liew, Chu W.

AU - Mackay, Joel P.

AU - Salleh, Hamzah M.

AU - Withers, Stephen G.

AU - McLeod, Malcolm D.

PY - 2008/4/17

Y1 - 2008/4/17

N2 - The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions.

AB - The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions.

UR - https://www.scopus.com/pages/publications/44449175733

U2 - 10.1021/ol8002767

DO - 10.1021/ol8002767

M3 - Article

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VL - 10

SP - 1585

EP - 1588

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

Escherichia coli glucuronylsynthase: An engineered enzyme for the synthesis of β-glucuronides

Abstract

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