Establishment of pediatric reference intervals on a large cohort of healthy children

Emma K. Southcott; Jennifer L. Kerrigan; Julia M. Potter; Richard D. Telford; Paul Waring; Graham J. Reynolds; Antony R.A. Lafferty; Peter E. Hickman

doi:10.1016/j.cca.2010.06.018

Establishment of pediatric reference intervals on a large cohort of healthy children

Emma K. Southcott, Jennifer L. Kerrigan, Julia M. Potter, Richard D. Telford, Paul Waring, Graham J. Reynolds, Antony R.A. Lafferty, Peter E. Hickman^*

^*Corresponding author for this work

School of Medicine and Psychology

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Background: Reference intervals are essential in assessing the significance of laboratory results. There have been limited studies generating reference intervals from pediatric populations. We have studied a large cohort of healthy children on 3 separate occasions at 2. yearly intervals. Methods: 852 healthy 8. year old children were enrolled in a community-based multidisciplinary longitudinal study investigating how early physical activity contributes to health. The same children came back for reassessment at ages 10 and 12. years. Blood samples were analyzed for a total of 37 different chemistries, immunoassays or derived values. Results: Reference intervals were derived for all the analytes for males and females separately. Conclusion: Whilst our results are largely in agreement with previously published work, we have shown that for a number of analytes, previously published work is distorted by subclinical disease.

Original language	English
Pages (from-to)	1421-1427
Number of pages	7
Journal	Clinica Chimica Acta
Volume	411
Issue number	19-20
DOIs	https://doi.org/10.1016/j.cca.2010.06.018
Publication status	Published - Oct 2010

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title = "Establishment of pediatric reference intervals on a large cohort of healthy children",

abstract = "Background: Reference intervals are essential in assessing the significance of laboratory results. There have been limited studies generating reference intervals from pediatric populations. We have studied a large cohort of healthy children on 3 separate occasions at 2. yearly intervals. Methods: 852 healthy 8. year old children were enrolled in a community-based multidisciplinary longitudinal study investigating how early physical activity contributes to health. The same children came back for reassessment at ages 10 and 12. years. Blood samples were analyzed for a total of 37 different chemistries, immunoassays or derived values. Results: Reference intervals were derived for all the analytes for males and females separately. Conclusion: Whilst our results are largely in agreement with previously published work, we have shown that for a number of analytes, previously published work is distorted by subclinical disease.",

keywords = "Biomarkers, Children, Pediatric, Reference intervals",

author = "Southcott, {Emma K.} and Kerrigan, {Jennifer L.} and Potter, {Julia M.} and Telford, {Richard D.} and Paul Waring and Reynolds, {Graham J.} and Lafferty, {Antony R.A.} and Hickman, {Peter E.}",

year = "2010",

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doi = "10.1016/j.cca.2010.06.018",

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pages = "1421--1427",

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T1 - Establishment of pediatric reference intervals on a large cohort of healthy children

AU - Southcott, Emma K.

AU - Kerrigan, Jennifer L.

AU - Potter, Julia M.

AU - Telford, Richard D.

AU - Waring, Paul

AU - Reynolds, Graham J.

AU - Lafferty, Antony R.A.

AU - Hickman, Peter E.

PY - 2010/10

Y1 - 2010/10

N2 - Background: Reference intervals are essential in assessing the significance of laboratory results. There have been limited studies generating reference intervals from pediatric populations. We have studied a large cohort of healthy children on 3 separate occasions at 2. yearly intervals. Methods: 852 healthy 8. year old children were enrolled in a community-based multidisciplinary longitudinal study investigating how early physical activity contributes to health. The same children came back for reassessment at ages 10 and 12. years. Blood samples were analyzed for a total of 37 different chemistries, immunoassays or derived values. Results: Reference intervals were derived for all the analytes for males and females separately. Conclusion: Whilst our results are largely in agreement with previously published work, we have shown that for a number of analytes, previously published work is distorted by subclinical disease.

AB - Background: Reference intervals are essential in assessing the significance of laboratory results. There have been limited studies generating reference intervals from pediatric populations. We have studied a large cohort of healthy children on 3 separate occasions at 2. yearly intervals. Methods: 852 healthy 8. year old children were enrolled in a community-based multidisciplinary longitudinal study investigating how early physical activity contributes to health. The same children came back for reassessment at ages 10 and 12. years. Blood samples were analyzed for a total of 37 different chemistries, immunoassays or derived values. Results: Reference intervals were derived for all the analytes for males and females separately. Conclusion: Whilst our results are largely in agreement with previously published work, we have shown that for a number of analytes, previously published work is distorted by subclinical disease.

KW - Biomarkers

KW - Children

KW - Pediatric

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DO - 10.1016/j.cca.2010.06.018

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JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

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ER -

Establishment of pediatric reference intervals on a large cohort of healthy children

Abstract

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