Euplectin and coneuplectin, new naphthopyrones from the lichen Flavoparmelia euplecta

Michael A. Ernst-Russell, Christina L.L. Chai, Judith H. Wardlaw, John A. Elix*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    84 Citations (Scopus)

    Abstract

    Two new naphthopyrones, euplectin (1) and coneuplectin (2), have been isolated 'from the lichen Flavoparmelia euplecta and their structures elucidated using multidimensional NMR spectroscopic methods, including highfield (600 MHz) gHMBC and gNOE experiments. Cytotoxicity of the more abundant naphthopyrone (1) against the murine P-815 mastocytoma cell line (IC50 ca. 1.67 μg/mL) has also been evaluated. These compounds are the first lichen metabolites known to contain indenone or indanone moieties in their structure. F. euplecta was also found to contain the known metabolites usnic acid, protocetraric acid, and skyrin.

    Original languageEnglish
    Pages (from-to)129-131
    Number of pages3
    JournalJournal of Natural Products
    Volume63
    Issue number1
    DOIs
    Publication statusPublished - 2000

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