TY - JOUR
T1 - Euplectin and coneuplectin, new naphthopyrones from the lichen Flavoparmelia euplecta
AU - Ernst-Russell, Michael A.
AU - Chai, Christina L.L.
AU - Wardlaw, Judith H.
AU - Elix, John A.
PY - 2000
Y1 - 2000
N2 - Two new naphthopyrones, euplectin (1) and coneuplectin (2), have been isolated 'from the lichen Flavoparmelia euplecta and their structures elucidated using multidimensional NMR spectroscopic methods, including highfield (600 MHz) gHMBC and gNOE experiments. Cytotoxicity of the more abundant naphthopyrone (1) against the murine P-815 mastocytoma cell line (IC50 ca. 1.67 μg/mL) has also been evaluated. These compounds are the first lichen metabolites known to contain indenone or indanone moieties in their structure. F. euplecta was also found to contain the known metabolites usnic acid, protocetraric acid, and skyrin.
AB - Two new naphthopyrones, euplectin (1) and coneuplectin (2), have been isolated 'from the lichen Flavoparmelia euplecta and their structures elucidated using multidimensional NMR spectroscopic methods, including highfield (600 MHz) gHMBC and gNOE experiments. Cytotoxicity of the more abundant naphthopyrone (1) against the murine P-815 mastocytoma cell line (IC50 ca. 1.67 μg/mL) has also been evaluated. These compounds are the first lichen metabolites known to contain indenone or indanone moieties in their structure. F. euplecta was also found to contain the known metabolites usnic acid, protocetraric acid, and skyrin.
UR - http://www.scopus.com/inward/record.url?scp=0033952894&partnerID=8YFLogxK
U2 - 10.1021/np9903245
DO - 10.1021/np9903245
M3 - Article
SN - 0163-3864
VL - 63
SP - 129
EP - 131
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 1
ER -