Evidence for gliotoxin-glutathione conjugate adducts

Paul H. Bernardo, Christina L.L. Chai*, Geoffrey J. Deeble, Xue Ming Liu, Paul Waring

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.

    Original languageEnglish
    Pages (from-to)483-485
    Number of pages3
    JournalBioorganic and Medicinal Chemistry Letters
    Volume11
    Issue number4
    DOIs
    Publication statusPublished - 26 Feb 2001

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