Evidence for gliotoxin-glutathione conjugate adducts

Paul H. Bernardo; Christina L.L. Chai; Geoffrey J. Deeble; Xue Ming Liu; Paul Waring

doi:10.1016/S0960-894X(00)00696-X

Evidence for gliotoxin-glutathione conjugate adducts

Paul H. Bernardo
, Christina L.L. Chai^*
, Geoffrey J. Deeble
, Xue Ming Liu
, Paul Waring

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M^-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.

Original language	English
Pages (from-to)	483-485
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/S0960-894X(00)00696-X
Publication status	Published - 26 Feb 2001

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@article{79fa15fe0e474c6f903ff51bf9fd47aa,

title = "Evidence for gliotoxin-glutathione conjugate adducts",

abstract = "The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.",

author = "Bernardo, \{Paul H.\} and Chai, \{Christina L.L.\} and Deeble, \{Geoffrey J.\} and Liu, \{Xue Ming\} and Paul Waring",

year = "2001",

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day = "26",

doi = "10.1016/S0960-894X(00)00696-X",

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T1 - Evidence for gliotoxin-glutathione conjugate adducts

AU - Bernardo, Paul H.

AU - Chai, Christina L.L.

AU - Deeble, Geoffrey J.

AU - Liu, Xue Ming

AU - Waring, Paul

PY - 2001/2/26

Y1 - 2001/2/26

N2 - The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.

AB - The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200±100M-1 at pH 7.0 at 25°C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.

UR - https://www.scopus.com/pages/publications/0035952310

U2 - 10.1016/S0960-894X(00)00696-X

DO - 10.1016/S0960-894X(00)00696-X

M3 - Article

SN - 0960-894X

VL - 11

SP - 483

EP - 485

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Evidence for gliotoxin-glutathione conjugate adducts

Abstract

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