Evolution of microcin V and colicin Ia plasmids in Escherichia coli

Anne Jeziorowski, David M. Gordon*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)


    Survey results and genotypic characterization of Escherichia coli strains demonstrate that the baeteriocins colicin Ia and microcin V coassociate in a strain more often than would be expected by chance. When these two baeteriocins co-occur, they are encoded on the same conjugative plasmid. Plasmids encoding colicin Ia and microcin V are nonrandomly distributed with respect to the genomic background of the host strain. Characterization of microcin V and colicin Ia nucleotide variation, together with the backbone of plasmids encoding these baeteriocins, indicates that the association has evolved on multiple occasions and involves the movement of the microcin V operon, together with the genes iroNEDCB and iss, onto a nonrandom subset of colicin Ia plasmids. The fitness advantage conferred on cells encoding both colicin Ia and microcin V has yet to be determined.

    Original languageEnglish
    Pages (from-to)7045-7052
    Number of pages8
    JournalJournal of Bacteriology
    Issue number19
    Publication statusPublished - Oct 2007


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