Excitatory actions of GABA in the cortex

Allan T. Gulledge, Greg J. Stuart*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    327 Citations (Scopus)

    Abstract

    Little is known about how GABAergic inputs interact with excitatory inputs under conditions that maintain physiological concentrations of intracellular anions. Using extracellular and gramicidin perforated-patch recording, we show that somatic and dendritic GABA responses in mature cortical pyramidal neurons are depolarizing from rest and can facilitate action potential generation when combined with proximal excitatory input. Dendritic GABA responses were excitatory regardless of timing, whereas somatic GABA responses were inhibitory when coincident with excitatory input but excitatory at earlier times. These excitatory actions of GABA occur even though the GABA reversal potential is below action potential threshold and largely uniform across the somato-dendritic axis, and arise when GABAergic inputs are temporally or spatially isolated from concurrent excitation. Our findings demonstrate that under certain circumstances GABA will have an excitatory role in synaptic integration in the cortex.

    Original languageEnglish
    Pages (from-to)299-309
    Number of pages11
    JournalNeuron
    Volume37
    Issue number2
    DOIs
    Publication statusPublished - 23 Jan 2003

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