Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a]indoles

Mohammad Mahdavi; Rasoul Hassanzadeh-Soureshjan; Mina Saeedi; Alireza Ariafard; Rasool Babaahmadi; Parviz Rashidi Ranjbar; Abbas Shafiee

doi:10.1039/c5ra17056g

Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a]indoles

Mohammad Mahdavi, Rasoul Hassanzadeh-Soureshjan, Mina Saeedi, Alireza Ariafard^*, Rasool Babaahmadi, Parviz Rashidi Ranjbar, Abbas Shafiee

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A novel series of oxopyrazino[1,2-a]indole derivatives were prepared via a two-step synthetic procedure including a Ugi-four-component reaction followed by the transition metal-free intramolecular hydroamination of Ugi adducts in the presence of KOt-Bu in DMF at room temperature. Density functional theory (DFT) calculations were also performed to elucidate the mechanistic aspects of the reaction.

Original language	English
Pages (from-to)	101353-101361
Number of pages	9
Journal	RSC Advances
Volume	5
Issue number	123
DOIs	https://doi.org/10.1039/c5ra17056g
Publication status	Published - 18 Nov 2015
Externally published	Yes

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title = "Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a]indoles",

abstract = "A novel series of oxopyrazino[1,2-a]indole derivatives were prepared via a two-step synthetic procedure including a Ugi-four-component reaction followed by the transition metal-free intramolecular hydroamination of Ugi adducts in the presence of KOt-Bu in DMF at room temperature. Density functional theory (DFT) calculations were also performed to elucidate the mechanistic aspects of the reaction.",

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AU - Mahdavi, Mohammad

AU - Hassanzadeh-Soureshjan, Rasoul

AU - Saeedi, Mina

AU - Ariafard, Alireza

AU - Babaahmadi, Rasool

AU - Ranjbar, Parviz Rashidi

AU - Shafiee, Abbas

PY - 2015/11/18

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AB - A novel series of oxopyrazino[1,2-a]indole derivatives were prepared via a two-step synthetic procedure including a Ugi-four-component reaction followed by the transition metal-free intramolecular hydroamination of Ugi adducts in the presence of KOt-Bu in DMF at room temperature. Density functional theory (DFT) calculations were also performed to elucidate the mechanistic aspects of the reaction.

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Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a]indoles

Abstract

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