Exploiting 4-1BB costimulation for enhancing antiviral vaccination

Jodie M. Harrison; Edward M. Bertram; Ian A. Ramshaw

doi:10.1089/vim.2006.19.593

Exploiting 4-1BB costimulation for enhancing antiviral vaccination

Jodie M. Harrison, Edward M. Bertram, Ian A. Ramshaw^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8⁺ T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8⁺ T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in terms of boosting antiviral vaccine responses.

Original language	English
Pages (from-to)	593-601
Number of pages	9
Journal	Viral Immunology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1089/vim.2006.19.593
Publication status	Published - 2006

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10.1089/vim.2006.19.593

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abstract = "4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8+ T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8+ T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in terms of boosting antiviral vaccine responses.",

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AB - 4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8+ T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8+ T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in terms of boosting antiviral vaccine responses.

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JO - Viral Immunology

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Exploiting 4-1BB costimulation for enhancing antiviral vaccination

Abstract

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