Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments

Paul B. Fitzgerald; Jerome J. Maller; Kate E. Hoy; Richard Thomson; Zafiris J. Daskalakis

doi:10.1016/j.brs.2009.03.002

Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments

Paul B. Fitzgerald^*, Jerome J. Maller, Kate E. Hoy, Richard Thomson, Zafiris J. Daskalakis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

Abstract

Background: Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols. Objective: The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies. Methods: Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established. Results: The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex. Conclusions: EEG points provide a useful way to optimally identify DLPFC.

Original language	English
Pages (from-to)	234-237
Number of pages	4
Journal	Brain Stimulation
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.brs.2009.03.002
Publication status	Published - Oct 2009
Externally published	Yes

Access to Document

10.1016/j.brs.2009.03.002

Cite this

@article{d74cf4f4465f4470a03e39faf2da7360,

title = "Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments",

abstract = "Background: Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols. Objective: The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies. Methods: Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established. Results: The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex. Conclusions: EEG points provide a useful way to optimally identify DLPFC.",

keywords = "antidepressant, depression, prefrontal cortex, remission, repetitive transcranial magnetic stimulation, response",

author = "Fitzgerald, {Paul B.} and Maller, {Jerome J.} and Hoy, {Kate E.} and Richard Thomson and Daskalakis, {Zafiris J.}",

year = "2009",

month = oct,

doi = "10.1016/j.brs.2009.03.002",

language = "English",

volume = "2",

pages = "234--237",

journal = "Brain Stimulation",

issn = "1935-861X",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments

AU - Fitzgerald, Paul B.

AU - Maller, Jerome J.

AU - Hoy, Kate E.

AU - Thomson, Richard

AU - Daskalakis, Zafiris J.

PY - 2009/10

Y1 - 2009/10

N2 - Background: Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols. Objective: The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies. Methods: Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established. Results: The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex. Conclusions: EEG points provide a useful way to optimally identify DLPFC.

AB - Background: Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols. Objective: The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies. Methods: Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established. Results: The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex. Conclusions: EEG points provide a useful way to optimally identify DLPFC.

KW - antidepressant

KW - depression

KW - prefrontal cortex

KW - remission

KW - repetitive transcranial magnetic stimulation

KW - response

UR - http://www.scopus.com/inward/record.url?scp=70349838066&partnerID=8YFLogxK

U2 - 10.1016/j.brs.2009.03.002

DO - 10.1016/j.brs.2009.03.002

M3 - Article

SN - 1935-861X

VL - 2

SP - 234

EP - 237

JO - Brain Stimulation

JF - Brain Stimulation

IS - 4

ER -

Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments

Abstract

Access to Document

Other files and links

Fingerprint

Cite this