Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments

Paul B. Fitzgerald; Jerome J. Maller; Kate E. Hoy; Richard Thomson; Zafiris J. Daskalakis

doi:10.1016/j.brs.2009.03.002

Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments

Paul B. Fitzgerald^*
, Jerome J. Maller
, Kate E. Hoy
, Richard Thomson
, Zafiris J. Daskalakis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

149 Citations (Scopus)

Abstract

Background: Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols. Objective: The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies. Methods: Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established. Results: The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex. Conclusions: EEG points provide a useful way to optimally identify DLPFC.

Original language	English
Pages (from-to)	234-237
Number of pages	4
Journal	Brain Stimulation
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.brs.2009.03.002
Publication status	Published - Oct 2009
Externally published	Yes

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10.1016/j.brs.2009.03.002

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title = "Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments",

abstract = "Background: Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols. Objective: The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies. Methods: Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established. Results: The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex. Conclusions: EEG points provide a useful way to optimally identify DLPFC.",

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AU - Maller, Jerome J.

AU - Hoy, Kate E.

AU - Thomson, Richard

AU - Daskalakis, Zafiris J.

PY - 2009/10

Y1 - 2009/10

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KW - remission

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KW - response

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JO - Brain Stimulation

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Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments

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