Extrafollicular antibody responses

Ian C.M. MacLennan; Kai Michael Toellner; Adam F. Cunningham; Karine Serre; Daniel M.Y. Sze; Elina Zúñiga; Matthew C. Cook; Carola G. Vinuesa

doi:10.1034/j.1600-065X.2003.00058.x

Extrafollicular antibody responses

Ian C.M. MacLennan^*, Kai Michael Toellner, Adam F. Cunningham, Karine Serre, Daniel M.Y. Sze, Elina Zúñiga, Matthew C. Cook, Carola G. Vinuesa

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

495 Citations (Scopus)

Abstract

In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.

Original language	English
Pages (from-to)	8-18
Number of pages	11
Journal	Immunological Reviews
Volume	194
DOIs	https://doi.org/10.1034/j.1600-065X.2003.00058.x
Publication status	Published - Aug 2003
Externally published	Yes

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@article{0592a9ffe0c9475696929bb458020f8b,

title = "Extrafollicular antibody responses",

abstract = "In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of na{\"i}ve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.",

author = "MacLennan, {Ian C.M.} and Toellner, {Kai Michael} and Cunningham, {Adam F.} and Karine Serre and Sze, {Daniel M.Y.} and Elina Z{\'u}{\~n}iga and Cook, {Matthew C.} and Vinuesa, {Carola G.}",

year = "2003",

month = aug,

doi = "10.1034/j.1600-065X.2003.00058.x",

language = "English",

volume = "194",

pages = "8--18",

journal = "Immunological Reviews",

issn = "0105-2896",

publisher = "Wiley-Blackwell Publishing Ltd",

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TY - JOUR

T1 - Extrafollicular antibody responses

AU - MacLennan, Ian C.M.

AU - Toellner, Kai Michael

AU - Cunningham, Adam F.

AU - Serre, Karine

AU - Sze, Daniel M.Y.

AU - Zúñiga, Elina

AU - Cook, Matthew C.

AU - Vinuesa, Carola G.

PY - 2003/8

Y1 - 2003/8

N2 - In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.

AB - In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.

UR - http://www.scopus.com/inward/record.url?scp=0038675204&partnerID=8YFLogxK

U2 - 10.1034/j.1600-065X.2003.00058.x

DO - 10.1034/j.1600-065X.2003.00058.x

M3 - Review article

SN - 0105-2896

VL - 194

SP - 8

EP - 18

JO - Immunological Reviews

JF - Immunological Reviews

ER -

Extrafollicular antibody responses

Abstract

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