Fabrication and cyto-compatibility of Fe3O4/SiO2/graphene-CdTe QDs/CS nanocomposites for drug delivery

Jun Ou; Fang Wang; Yuanjie Huang; Duosheng Li; Yuming Jiang; Qing Hua Qin; Z. H. Stachurski; Antonio Tricoli; Tina Zhang

doi:10.1016/j.colsurfb.2013.12.003

Fabrication and cyto-compatibility of Fe₃O₄/SiO₂/graphene-CdTe QDs/CS nanocomposites for drug delivery

Jun Ou^*, Fang Wang, Yuanjie Huang, Duosheng Li, Yuming Jiang, Qing Hua Qin, Z. H. Stachurski, Antonio Tricoli, Tina Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Synthesis of magnetic Fe₃O₄/SiO₂/graphene-CdTe QDs/chitosan nanocomposites (FGQCs) is investigated with respect to their potential of improving the drug loading content above that of magnetic/fluorescent bifunctional nanocomposites. To evaluate the performance of the FGQCs, their surface morphology was thoroughly assessed. The in vitro interaction between the FGQCs and heptoma cell line smmc-7721 cells was observed for the first time by TEM ultrathin section imaging. At an excitation wavelength of 365nm, the graphene-QDs exhibit a strong luminescence in aqueous environments. The loading content and entrapment efficiency of the FGQCs were 70% and 50%, respectively. The cytotoxicity of this novel drug delivery system was evaluated in vitro using heptoma cell line smmc-7721 and quantified by the 3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that FGQCs are a promising new multifunctional material for drug delivery in biological and medical applications.

Original language	English
Pages (from-to)	466-472
Number of pages	7
Journal	Colloids and Surfaces B: Biointerfaces
Volume	117
DOIs	https://doi.org/10.1016/j.colsurfb.2013.12.003
Publication status	Published - 1 May 2014

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10.1016/j.colsurfb.2013.12.003

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@article{38676d86bd0045849ae16a9fbaf892e9,

title = "Fabrication and cyto-compatibility of Fe3O4/SiO2/graphene-CdTe QDs/CS nanocomposites for drug delivery",

abstract = "Synthesis of magnetic Fe3O4/SiO2/graphene-CdTe QDs/chitosan nanocomposites (FGQCs) is investigated with respect to their potential of improving the drug loading content above that of magnetic/fluorescent bifunctional nanocomposites. To evaluate the performance of the FGQCs, their surface morphology was thoroughly assessed. The in vitro interaction between the FGQCs and heptoma cell line smmc-7721 cells was observed for the first time by TEM ultrathin section imaging. At an excitation wavelength of 365nm, the graphene-QDs exhibit a strong luminescence in aqueous environments. The loading content and entrapment efficiency of the FGQCs were 70% and 50%, respectively. The cytotoxicity of this novel drug delivery system was evaluated in vitro using heptoma cell line smmc-7721 and quantified by the 3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that FGQCs are a promising new multifunctional material for drug delivery in biological and medical applications.",

keywords = "CdTe QDs, Drug delivery, Graphene cytotocity, Luminescence, Multifunctional",

author = "Jun Ou and Fang Wang and Yuanjie Huang and Duosheng Li and Yuming Jiang and Qin, {Qing Hua} and Stachurski, {Z. H.} and Antonio Tricoli and Tina Zhang",

year = "2014",

month = may,

day = "1",

doi = "10.1016/j.colsurfb.2013.12.003",

language = "English",

volume = "117",

pages = "466--472",

journal = "Colloids and Surfaces B: Biointerfaces",

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publisher = "Elsevier B.V.",

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T1 - Fabrication and cyto-compatibility of Fe3O4/SiO2/graphene-CdTe QDs/CS nanocomposites for drug delivery

AU - Ou, Jun

AU - Wang, Fang

AU - Huang, Yuanjie

AU - Li, Duosheng

AU - Jiang, Yuming

AU - Qin, Qing Hua

AU - Stachurski, Z. H.

AU - Tricoli, Antonio

AU - Zhang, Tina

PY - 2014/5/1

Y1 - 2014/5/1

N2 - Synthesis of magnetic Fe3O4/SiO2/graphene-CdTe QDs/chitosan nanocomposites (FGQCs) is investigated with respect to their potential of improving the drug loading content above that of magnetic/fluorescent bifunctional nanocomposites. To evaluate the performance of the FGQCs, their surface morphology was thoroughly assessed. The in vitro interaction between the FGQCs and heptoma cell line smmc-7721 cells was observed for the first time by TEM ultrathin section imaging. At an excitation wavelength of 365nm, the graphene-QDs exhibit a strong luminescence in aqueous environments. The loading content and entrapment efficiency of the FGQCs were 70% and 50%, respectively. The cytotoxicity of this novel drug delivery system was evaluated in vitro using heptoma cell line smmc-7721 and quantified by the 3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that FGQCs are a promising new multifunctional material for drug delivery in biological and medical applications.

AB - Synthesis of magnetic Fe3O4/SiO2/graphene-CdTe QDs/chitosan nanocomposites (FGQCs) is investigated with respect to their potential of improving the drug loading content above that of magnetic/fluorescent bifunctional nanocomposites. To evaluate the performance of the FGQCs, their surface morphology was thoroughly assessed. The in vitro interaction between the FGQCs and heptoma cell line smmc-7721 cells was observed for the first time by TEM ultrathin section imaging. At an excitation wavelength of 365nm, the graphene-QDs exhibit a strong luminescence in aqueous environments. The loading content and entrapment efficiency of the FGQCs were 70% and 50%, respectively. The cytotoxicity of this novel drug delivery system was evaluated in vitro using heptoma cell line smmc-7721 and quantified by the 3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that FGQCs are a promising new multifunctional material for drug delivery in biological and medical applications.

KW - CdTe QDs

KW - Drug delivery

KW - Graphene cytotocity

KW - Luminescence

KW - Multifunctional

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U2 - 10.1016/j.colsurfb.2013.12.003

DO - 10.1016/j.colsurfb.2013.12.003

M3 - Article

SN - 0927-7765

VL - 117

SP - 466

EP - 472

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

ER -

Fabrication and cyto-compatibility of Fe₃O₄/SiO₂/graphene-CdTe QDs/CS nanocomposites for drug delivery

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