Fast and slow feedforward inhibitory circuits for cortical odor processing

Norimitsu Suzuki; Malinda L.S. Tantirigama; K. Phyu Aung; Helena H.Y. Huang; John M. Bekkers

doi:10.7554/eLife.73406

Fast and slow feedforward inhibitory circuits for cortical odor processing

Norimitsu Suzuki, Malinda L.S. Tantirigama, K. Phyu Aung, Helena H.Y. Huang, John M. Bekkers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Feedforward inhibitory circuits are key contributors to the complex interplay between excitation and inhibition in the brain. Little is known about the function of feedforward inhibition in the primary olfactory (piriform) cortex. Using in vivo two-photon-targeted patch clamping and calcium imaging in mice, we find that odors evoke strong excitation in two classes of interneurons – neurogliaform (NG) cells and horizontal (HZ) cells – that provide feedforward inhibition in layer 1 of the piriform cortex. NG cells fire much earlier than HZ cells following odor onset, a difference that can be attributed to the faster odor-driven excitatory synaptic drive that NG cells receive from the olfactory bulb. As a result, NG cells strongly but transiently inhibit odor-evoked excitation in layer 2 principal cells, whereas HZ cells provide more diffuse and prolonged feedforward inhibition. Our findings reveal unexpected complexity in the operation of inhibition in the piriform cortex.

Original language	English
Article number	e73406
Number of pages	29
Journal	eLife
Volume	11
DOIs	https://doi.org/10.7554/eLife.73406
Publication status	Published - 17 Mar 2022

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10.7554/eLife.73406Licence: CC BY

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title = "Fast and slow feedforward inhibitory circuits for cortical odor processing",

abstract = "Feedforward inhibitory circuits are key contributors to the complex interplay between excitation and inhibition in the brain. Little is known about the function of feedforward inhibition in the primary olfactory (piriform) cortex. Using in vivo two-photon-targeted patch clamping and calcium imaging in mice, we find that odors evoke strong excitation in two classes of interneurons – neurogliaform (NG) cells and horizontal (HZ) cells – that provide feedforward inhibition in layer 1 of the piriform cortex. NG cells fire much earlier than HZ cells following odor onset, a difference that can be attributed to the faster odor-driven excitatory synaptic drive that NG cells receive from the olfactory bulb. As a result, NG cells strongly but transiently inhibit odor-evoked excitation in layer 2 principal cells, whereas HZ cells provide more diffuse and prolonged feedforward inhibition. Our findings reveal unexpected complexity in the operation of inhibition in the piriform cortex.",

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AU - Suzuki, Norimitsu

AU - Tantirigama, Malinda L.S.

AU - Aung, K. Phyu

AU - Huang, Helena H.Y.

AU - Bekkers, John M.

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Fast and slow feedforward inhibitory circuits for cortical odor processing

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