TY - JOUR
T1 - Finding a Needle in a Haystack – In Silico Search for Environmental Traces of Candida auris
AU - Irinyi, Laszlo
AU - Roper, Michael
AU - Malik, Richard
AU - Meyer, Wieland
PY - 2022
Y1 - 2022
N2 - Candida auris, first described from an ear infection in Japan, is the most talked about multidrug resistant emerging pathogenic fungal species. Its environmental niche remained a mystery until its first isolation from wetlands of the Andaman Islands, India in 2020. We screened a subset of the world's largest sequence repository, the Sequence Read Archive at NCBI using a DNA metabarcoding approach, based on either the ITS1 or ITS2 region of the official primary fungal DNA barcode, to identify potential environmental sources of C. auris. Our search identified 34 matches with partial C. auris ITS sequences from seven metabarcoding studies, providing wider evidence for the presence of C. auris outside human-maintained facilities.
AB - Candida auris, first described from an ear infection in Japan, is the most talked about multidrug resistant emerging pathogenic fungal species. Its environmental niche remained a mystery until its first isolation from wetlands of the Andaman Islands, India in 2020. We screened a subset of the world's largest sequence repository, the Sequence Read Archive at NCBI using a DNA metabarcoding approach, based on either the ITS1 or ITS2 region of the official primary fungal DNA barcode, to identify potential environmental sources of C. auris. Our search identified 34 matches with partial C. auris ITS sequences from seven metabarcoding studies, providing wider evidence for the presence of C. auris outside human-maintained facilities.
U2 - 10.7883/yoken.JJID.2022.068
DO - 10.7883/yoken.JJID.2022.068
M3 - Article
VL - 75
SP - 490
EP - 495
JO - Japanese Journal of Infectious Diseases
JF - Japanese Journal of Infectious Diseases
IS - 5
ER -