Fluctuating selection and the determinants of genetic variation

Olivia L. Johnson; Raymond Tobler; Joshua M. Schmidt; Christian D. Huber

doi:10.1016/j.tig.2023.02.004

Fluctuating selection and the determinants of genetic variation

Olivia L. Johnson, Raymond Tobler, Joshua M. Schmidt, Christian D. Huber^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating selection to the forefront of the historical debate surrounding the maintenance of genetic variation in natural populations. Numerous mechanisms have been explored in this longstanding area of research, but these exciting empirical findings have prompted several recent theoretical and experimental studies that seek to better understand the drivers, dynamics, and genome-wide influence of fluctuating selection. In this review, we evaluate the latest evidence for multilocus fluctuating selection in Drosophila and other taxa, highlighting the role of potential genetic and ecological mechanisms in maintaining these loci and their impacts on neutral genetic variation.

Original language	English
Pages (from-to)	491-504
Number of pages	14
Journal	Trends in Genetics
Volume	39
Issue number	6
DOIs	https://doi.org/10.1016/j.tig.2023.02.004
Publication status	Published - Jun 2023

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10.1016/j.tig.2023.02.004

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title = "Fluctuating selection and the determinants of genetic variation",

abstract = "Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating selection to the forefront of the historical debate surrounding the maintenance of genetic variation in natural populations. Numerous mechanisms have been explored in this longstanding area of research, but these exciting empirical findings have prompted several recent theoretical and experimental studies that seek to better understand the drivers, dynamics, and genome-wide influence of fluctuating selection. In this review, we evaluate the latest evidence for multilocus fluctuating selection in Drosophila and other taxa, highlighting the role of potential genetic and ecological mechanisms in maintaining these loci and their impacts on neutral genetic variation.",

keywords = "balancing selection, dominance reversal, fluctuating selection, genetic variation",

author = "Johnson, {Olivia L.} and Raymond Tobler and Schmidt, {Joshua M.} and Huber, {Christian D.}",

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AU - Johnson, Olivia L.

AU - Tobler, Raymond

AU - Schmidt, Joshua M.

AU - Huber, Christian D.

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N2 - Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating selection to the forefront of the historical debate surrounding the maintenance of genetic variation in natural populations. Numerous mechanisms have been explored in this longstanding area of research, but these exciting empirical findings have prompted several recent theoretical and experimental studies that seek to better understand the drivers, dynamics, and genome-wide influence of fluctuating selection. In this review, we evaluate the latest evidence for multilocus fluctuating selection in Drosophila and other taxa, highlighting the role of potential genetic and ecological mechanisms in maintaining these loci and their impacts on neutral genetic variation.

AB - Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating selection to the forefront of the historical debate surrounding the maintenance of genetic variation in natural populations. Numerous mechanisms have been explored in this longstanding area of research, but these exciting empirical findings have prompted several recent theoretical and experimental studies that seek to better understand the drivers, dynamics, and genome-wide influence of fluctuating selection. In this review, we evaluate the latest evidence for multilocus fluctuating selection in Drosophila and other taxa, highlighting the role of potential genetic and ecological mechanisms in maintaining these loci and their impacts on neutral genetic variation.

KW - balancing selection

KW - dominance reversal

KW - fluctuating selection

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VL - 39

SP - 491

EP - 504

JO - Trends in Genetics

JF - Trends in Genetics

IS - 6

ER -

Fluctuating selection and the determinants of genetic variation

Abstract

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