Fly fishing for GSTs: A unified nomenclature for mammalian and insect glutathione transferases

Gareth Chelvanayagama; Michael W. Parker; Philip G. Board

Fly fishing for GSTs: A unified nomenclature for mammalian and insect glutathione transferases

Gareth Chelvanayagama^*, Michael W. Parker, Philip G. Board

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

Previously, due to the paucity of sequence data, only two broad classes of glutathione transferases (GSTs) were identified in insects. The recent completion of the sequencing of the Drosophila melanogaster genome has allowed the identification of a considerable number of insect GSTs via a systematic comparison of the genome with sequences from established GST classes. Strikingly, many GST classes found in mammals also occur in Drosophila. These results suggest that the nomenclature originally proposed for invertebrates GSTs, can be extended to harmonise with that used for humans and other species.

Original language	English
Pages (from-to)	256-260
Number of pages	5
Journal	Chemico-Biological Interactions
Volume	133
Issue number	1-3
Publication status	Published - 28 Feb 2001

Cite this

@article{6ee6d4d10f634231b18f3cca1f2652f2,

title = "Fly fishing for GSTs: A unified nomenclature for mammalian and insect glutathione transferases",

abstract = "Previously, due to the paucity of sequence data, only two broad classes of glutathione transferases (GSTs) were identified in insects. The recent completion of the sequencing of the Drosophila melanogaster genome has allowed the identification of a considerable number of insect GSTs via a systematic comparison of the genome with sequences from established GST classes. Strikingly, many GST classes found in mammals also occur in Drosophila. These results suggest that the nomenclature originally proposed for invertebrates GSTs, can be extended to harmonise with that used for humans and other species.",

keywords = "GST classes, GST nomenclature, Glutathione transferase, Insect GSTs",

author = "Gareth Chelvanayagama and Parker, {Michael W.} and Board, {Philip G.}",

year = "2001",

month = feb,

day = "28",

language = "English",

volume = "133",

pages = "256--260",

journal = "Chemico-Biological Interactions",

issn = "0009-2797",

publisher = "Elsevier Ireland Ltd",

number = "1-3",

}

TY - JOUR

T1 - Fly fishing for GSTs

T2 - A unified nomenclature for mammalian and insect glutathione transferases

AU - Chelvanayagama, Gareth

AU - Parker, Michael W.

AU - Board, Philip G.

PY - 2001/2/28

Y1 - 2001/2/28

N2 - Previously, due to the paucity of sequence data, only two broad classes of glutathione transferases (GSTs) were identified in insects. The recent completion of the sequencing of the Drosophila melanogaster genome has allowed the identification of a considerable number of insect GSTs via a systematic comparison of the genome with sequences from established GST classes. Strikingly, many GST classes found in mammals also occur in Drosophila. These results suggest that the nomenclature originally proposed for invertebrates GSTs, can be extended to harmonise with that used for humans and other species.

AB - Previously, due to the paucity of sequence data, only two broad classes of glutathione transferases (GSTs) were identified in insects. The recent completion of the sequencing of the Drosophila melanogaster genome has allowed the identification of a considerable number of insect GSTs via a systematic comparison of the genome with sequences from established GST classes. Strikingly, many GST classes found in mammals also occur in Drosophila. These results suggest that the nomenclature originally proposed for invertebrates GSTs, can be extended to harmonise with that used for humans and other species.

KW - GST classes

KW - GST nomenclature

KW - Glutathione transferase

KW - Insect GSTs

UR - http://www.scopus.com/inward/record.url?scp=0000104664&partnerID=8YFLogxK

M3 - Article

SN - 0009-2797

VL - 133

SP - 256

EP - 260

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

IS - 1-3

ER -

Fly fishing for GSTs: A unified nomenclature for mammalian and insect glutathione transferases

Abstract

Other files and links

Fingerprint

Cite this