TY - GEN
T1 - Focal activation of primary visual cortex following supra-choroidal electrical stimulation of the retina
T2 - 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
AU - Cloherty, Shaun L.
AU - Hietanen, Markus A.
AU - Suaning, Gregg J.
AU - Ibbotson, Michael R.
PY - 2010
Y1 - 2010
N2 - We performed optical intrinsic signal imaging of cat primary visual cortex (Area 17 and 18) while delivering bipolar electrical stimulation to the retina by way of a suprachoroidal electrode array. Using a general linear model (GLM) analysis we identified statistically significant (p < 0.01) activation in a localized region of cortex following supra-threshold electrical stimulation at a single retinal locus. Our results: (1) demonstrate that intrinsic signal imaging combined with linear model analysis provides a powerful tool for assessing cortical responses to prosthetic stimulation, and (2) confirm that suprachoroidal electrical stimulation can achieve localized activation of the cortex consistent with focal activation of the retina.
AB - We performed optical intrinsic signal imaging of cat primary visual cortex (Area 17 and 18) while delivering bipolar electrical stimulation to the retina by way of a suprachoroidal electrode array. Using a general linear model (GLM) analysis we identified statistically significant (p < 0.01) activation in a localized region of cortex following supra-threshold electrical stimulation at a single retinal locus. Our results: (1) demonstrate that intrinsic signal imaging combined with linear model analysis provides a powerful tool for assessing cortical responses to prosthetic stimulation, and (2) confirm that suprachoroidal electrical stimulation can achieve localized activation of the cortex consistent with focal activation of the retina.
UR - http://www.scopus.com/inward/record.url?scp=78650845713&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2010.5625999
DO - 10.1109/IEMBS.2010.5625999
M3 - Conference contribution
SN - 9781424441235
T3 - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
SP - 6765
EP - 6768
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Y2 - 31 August 2010 through 4 September 2010
ER -