Formylated phloroglucinols from Eucalyptus loxophleba foliage

Jasmeen Sidana; Sukhvinder Singh; Sunil Kumar Arora; William J. Foley; Inder Pal Singh

doi:10.1016/j.fitote.2011.07.009

Formylated phloroglucinols from Eucalyptus loxophleba foliage

Jasmeen Sidana, Sukhvinder Singh, Sunil Kumar Arora, William J. Foley, Inder Pal Singh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Two new naturally occurring formylated phloroglucinol compounds (FPCs), a dimer, loxophlebal B (10) and a cyclized FPC, loxophlebene (8) together with eight other formylated phloroglucinols (1-7 and 9) were isolated from the chloroform-methanol (8:2) extract of the leaves of Eucalyptus loxophleba ssp. lissophloia. The structures of new compounds were established by comprehensive spectral analysis and by comparison of their NMR data with those of related compounds in the literature. All the isolated compounds were evaluated for anti-leishmanial activity against promastigotes of Leishmania donovani.

Original language	English
Pages (from-to)	1118-1122
Number of pages	5
Journal	Fitoterapia
Volume	82
Issue number	7
DOIs	https://doi.org/10.1016/j.fitote.2011.07.009
Publication status	Published - Oct 2011

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10.1016/j.fitote.2011.07.009

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title = "Formylated phloroglucinols from Eucalyptus loxophleba foliage",

abstract = "Two new naturally occurring formylated phloroglucinol compounds (FPCs), a dimer, loxophlebal B (10) and a cyclized FPC, loxophlebene (8) together with eight other formylated phloroglucinols (1-7 and 9) were isolated from the chloroform-methanol (8:2) extract of the leaves of Eucalyptus loxophleba ssp. lissophloia. The structures of new compounds were established by comprehensive spectral analysis and by comparison of their NMR data with those of related compounds in the literature. All the isolated compounds were evaluated for anti-leishmanial activity against promastigotes of Leishmania donovani.",

keywords = "Antileishmanial, Eucalyptus loxophleba, Euglobals, Formylated phloroglucinols, Grandinal, Loxophlebal A",

author = "Jasmeen Sidana and Sukhvinder Singh and Arora, {Sunil Kumar} and Foley, {William J.} and Singh, {Inder Pal}",

year = "2011",

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doi = "10.1016/j.fitote.2011.07.009",

language = "English",

volume = "82",

pages = "1118--1122",

journal = "Fitoterapia",

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TY - JOUR

T1 - Formylated phloroglucinols from Eucalyptus loxophleba foliage

AU - Sidana, Jasmeen

AU - Singh, Sukhvinder

AU - Arora, Sunil Kumar

AU - Foley, William J.

AU - Singh, Inder Pal

PY - 2011/10

Y1 - 2011/10

N2 - Two new naturally occurring formylated phloroglucinol compounds (FPCs), a dimer, loxophlebal B (10) and a cyclized FPC, loxophlebene (8) together with eight other formylated phloroglucinols (1-7 and 9) were isolated from the chloroform-methanol (8:2) extract of the leaves of Eucalyptus loxophleba ssp. lissophloia. The structures of new compounds were established by comprehensive spectral analysis and by comparison of their NMR data with those of related compounds in the literature. All the isolated compounds were evaluated for anti-leishmanial activity against promastigotes of Leishmania donovani.

AB - Two new naturally occurring formylated phloroglucinol compounds (FPCs), a dimer, loxophlebal B (10) and a cyclized FPC, loxophlebene (8) together with eight other formylated phloroglucinols (1-7 and 9) were isolated from the chloroform-methanol (8:2) extract of the leaves of Eucalyptus loxophleba ssp. lissophloia. The structures of new compounds were established by comprehensive spectral analysis and by comparison of their NMR data with those of related compounds in the literature. All the isolated compounds were evaluated for anti-leishmanial activity against promastigotes of Leishmania donovani.

KW - Antileishmanial

KW - Eucalyptus loxophleba

KW - Euglobals

KW - Formylated phloroglucinols

KW - Grandinal

KW - Loxophlebal A

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U2 - 10.1016/j.fitote.2011.07.009

DO - 10.1016/j.fitote.2011.07.009

M3 - Article

SN - 0367-326X

VL - 82

SP - 1118

EP - 1122

JO - Fitoterapia

JF - Fitoterapia

IS - 7

ER -

Formylated phloroglucinols from Eucalyptus loxophleba foliage

Abstract

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