Four-Step Total Synthesis of Selaginpulvilin D

Madison J. Sowden; Michael S. Sherburn

doi:10.1021/acs.orglett.6b03793

Four-Step Total Synthesis of Selaginpulvilin D

Madison J. Sowden, Michael S. Sherburn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

An extremely concise total synthesis of a potent phosphodiesterase-4 inhibitory natural product, selaginpulvilin D, is reported. The synthesis features a one-pot, 3-fold electrophilic aromatic substitution sequence to assemble a 9,9-diarylfluorene core. The approach allows access to useful quantities of a selaginpulvilin natural product for the first time.

Original language	English
Pages (from-to)	636-637
Number of pages	2
Journal	Organic Letters
Volume	19
Issue number	3
DOIs	https://doi.org/10.1021/acs.orglett.6b03793
Publication status	Published - 3 Feb 2017

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title = "Four-Step Total Synthesis of Selaginpulvilin D",

abstract = "An extremely concise total synthesis of a potent phosphodiesterase-4 inhibitory natural product, selaginpulvilin D, is reported. The synthesis features a one-pot, 3-fold electrophilic aromatic substitution sequence to assemble a 9,9-diarylfluorene core. The approach allows access to useful quantities of a selaginpulvilin natural product for the first time.",

author = "Sowden, {Madison J.} and Sherburn, {Michael S.}",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

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doi = "10.1021/acs.orglett.6b03793",

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AU - Sowden, Madison J.

AU - Sherburn, Michael S.

PY - 2017/2/3

Y1 - 2017/2/3

N2 - An extremely concise total synthesis of a potent phosphodiesterase-4 inhibitory natural product, selaginpulvilin D, is reported. The synthesis features a one-pot, 3-fold electrophilic aromatic substitution sequence to assemble a 9,9-diarylfluorene core. The approach allows access to useful quantities of a selaginpulvilin natural product for the first time.

AB - An extremely concise total synthesis of a potent phosphodiesterase-4 inhibitory natural product, selaginpulvilin D, is reported. The synthesis features a one-pot, 3-fold electrophilic aromatic substitution sequence to assemble a 9,9-diarylfluorene core. The approach allows access to useful quantities of a selaginpulvilin natural product for the first time.

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U2 - 10.1021/acs.orglett.6b03793

DO - 10.1021/acs.orglett.6b03793

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SP - 636

EP - 637

JO - Organic Letters

JF - Organic Letters

IS - 3

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Four-Step Total Synthesis of Selaginpulvilin D

Abstract

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