Frequency doubling illusion VEPs and automated perimetry in multiple sclerosis

Rasa Ruseckaite*, Teddy Maddess, Gytis Danta, Andrew Charles James

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    We examined frequency doubling (FD) illusion based automated perimetry (FDT) and dichoptic FD multifocal visual evoked potentials (FDmfVEPs) in Normal and multiple sclerosis (MS) subjects. Contrast thresholds were determined at 17 visual field locations using an FDT perimeter. The stimuli presented to each location were 0.25 cpd gratings presented with rapid (25 Hz) counterphase flicker and thus displayed the spatial FD illusion. Dichoptic mfVEPs were recorded by concurrently stimulating eight regions/eye with FD stimuli presented at 95% contrast. Recordings were obtained from 27 Normal subjects, 26 MS patients who had experienced Optic Neuritis (MSON) and 24 MS patients without a history of ON (MSNON). The FDT thresholds showed enhanced contrast sensitivity for MSON patients (P < 0.0001) but not for MSNON patients. Response amplitudes for the central four regions of the mfVEP stimulus were reduced in both patient groups (P < 0.005). A classification model based upon the FDT thresholds performed at a specificity of 96% for a sensitivity of 97% in MSON patients, but the accuracy (simultaneously largest sensitivities and specificities) was poor (∼60%) in MSNON patients. Discriminant models based on the FDT thresholds and FDmfVEPs were able to diagnose more that 90% MSON patients but performed poorly for MSNON patients.

    Original languageEnglish
    Pages (from-to)29-41
    Number of pages13
    JournalDocumenta Ophthalmologica
    Volume113
    Issue number1
    DOIs
    Publication statusPublished - Jul 2006

    Fingerprint

    Dive into the research topics of 'Frequency doubling illusion VEPs and automated perimetry in multiple sclerosis'. Together they form a unique fingerprint.

    Cite this