Frequency of cancer genes on the chicken Z chromosome and its human homologues: Implications for sex chromosome evolution

Rami Stiglec; Matthias Kohn; James Fong; Tariq Ezzaz; Horst Hameister; Jennifer A. Marshall Graves

doi:10.1155/2007/43070

Frequency of cancer genes on the chicken Z chromosome and its human homologues: Implications for sex chromosome evolution

Rami Stiglec^*, Matthias Kohn, James Fong, Tariq Ezzaz, Horst Hameister, Jennifer A. Marshall Graves

^*Corresponding author for this work

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Abstract

It has been suggested that there are special evolutionary forces that act on sex chromosomes. Hemizygosity of the X chromosome in male mammals has led to selection for male-advantage genes, and against genes posing extreme risks of tumor development. A similar bias against cancer genes should also apply to the Z chromosome that is present as a single copy in female birds. Using comparative database analysis, we found that there was no significant underrepresentation of cancer genes on the chicken Z, nor on the Z-orthologous regions of human chromosomes 5 and 9. This result does not support the hypothesis that genes involved in cancer are selected against on the sex chromosomes.

Original language	English
Article number	43070
Journal	Comparative and Functional Genomics
Volume	2007
DOIs	https://doi.org/10.1155/2007/43070
Publication status	Published - 2007

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AU - Ezzaz, Tariq

AU - Hameister, Horst

AU - Marshall Graves, Jennifer A.

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JO - Comparative and Functional Genomics

JF - Comparative and Functional Genomics

M1 - 43070

ER -

Frequency of cancer genes on the chicken Z chromosome and its human homologues: Implications for sex chromosome evolution

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