Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer

Shaohua Chen; Daohai Zhang

doi:10.1016/j.fob.2015.01.004

Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer

Shaohua Chen, Daohai Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor development and functions as a tumor suppressor by inducing cell growth arrest in breast cancer. However, ERp29 has also been reported to promote epithelial cell morphogenesis, cell survival against genotoxic stress and distant metastasis. In this review, we summarize the current understanding on the biological and pathological functions of ERp29 in cancer and discuss the pivotal aspects of ERp29 as "friend or foe" in epithelial cancer.

Original language	English
Pages (from-to)	91-98
Number of pages	8
Journal	FEBS Open Bio
Volume	5
DOIs	https://doi.org/10.1016/j.fob.2015.01.004
Publication status	Published - 1 Jan 2015

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10.1016/j.fob.2015.01.004

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title = "Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer",

abstract = "The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor development and functions as a tumor suppressor by inducing cell growth arrest in breast cancer. However, ERp29 has also been reported to promote epithelial cell morphogenesis, cell survival against genotoxic stress and distant metastasis. In this review, we summarize the current understanding on the biological and pathological functions of ERp29 in cancer and discuss the pivotal aspects of ERp29 as {"}friend or foe{"} in epithelial cancer.",

keywords = "Chemo-/radio-resistance, DNA stability, ERp29, Epithelial cell plasticity, Mesenchymal-epithelial transition, Metastasis",

author = "Shaohua Chen and Daohai Zhang",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

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doi = "10.1016/j.fob.2015.01.004",

language = "English",

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T2 - Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer

AU - Chen, Shaohua

AU - Zhang, Daohai

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor development and functions as a tumor suppressor by inducing cell growth arrest in breast cancer. However, ERp29 has also been reported to promote epithelial cell morphogenesis, cell survival against genotoxic stress and distant metastasis. In this review, we summarize the current understanding on the biological and pathological functions of ERp29 in cancer and discuss the pivotal aspects of ERp29 as "friend or foe" in epithelial cancer.

AB - The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor development and functions as a tumor suppressor by inducing cell growth arrest in breast cancer. However, ERp29 has also been reported to promote epithelial cell morphogenesis, cell survival against genotoxic stress and distant metastasis. In this review, we summarize the current understanding on the biological and pathological functions of ERp29 in cancer and discuss the pivotal aspects of ERp29 as "friend or foe" in epithelial cancer.

KW - Chemo-/radio-resistance

KW - DNA stability

KW - ERp29

KW - Epithelial cell plasticity

KW - Mesenchymal-epithelial transition

KW - Metastasis

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DO - 10.1016/j.fob.2015.01.004

M3 - Review article

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VL - 5

SP - 91

EP - 98

JO - FEBS Open Bio

JF - FEBS Open Bio

ER -

Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer

Abstract

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