From cis-regulatory elements to complex RNPs and back

F Gebauer, Thomas Preiss, Matthias Hentze

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Messenger RNAs (mRNAs), the templates for translation, have evolved to harbor abundant cis-acting sequences that affect their posttranscriptional fates. These elements are frequently located in the untranslated regions and serve as binding sites for trans-acting factors, RNA-binding proteins, and/or small non-coding RNAs. This article provides a systematic synopsis of cis-acting elements, trans-acting factors, and the mechanisms by which they affect translation. It also highlights recent technical advances that have ushered in the era of transcriptome-wide studies of the ribonucleoprotein complexes formed by mRNAs and their trans-acting factors.
    Original languageEnglish
    Pages (from-to)1-14
    JournalCold Spring Harbor Perspectives in Biology
    Volume4
    Issue number7
    DOIs
    Publication statusPublished - 2012

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