Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades

Shaohua Chen; Yang Zhao; Yu Zhang; Daohai Zhang

doi:10.1371/journal.pone.0108157

Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades

Shaohua Chen^*
, Yang Zhao
, Yu Zhang
, Daohai Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

p Conclusion/Significance: Fucoidan exerts its anti-tumor function by modulating ER stress cascades. Contribution of ER stress to the fucoidan-induced cell apoptosis augments our understanding of the molecular mechanisms underlying its antitumour activity and provides evidence for the therapeutic application of fucoidan in cancer.

Original language	English
Article number	e108157
Journal	PLoS ONE
Volume	9
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0108157
Publication status	Published - 18 Sept 2014

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title = "Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades",

abstract = "p Conclusion/Significance: Fucoidan exerts its anti-tumor function by modulating ER stress cascades. Contribution of ER stress to the fucoidan-induced cell apoptosis augments our understanding of the molecular mechanisms underlying its antitumour activity and provides evidence for the therapeutic application of fucoidan in cancer.",

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N2 - p Conclusion/Significance: Fucoidan exerts its anti-tumor function by modulating ER stress cascades. Contribution of ER stress to the fucoidan-induced cell apoptosis augments our understanding of the molecular mechanisms underlying its antitumour activity and provides evidence for the therapeutic application of fucoidan in cancer.

AB - p Conclusion/Significance: Fucoidan exerts its anti-tumor function by modulating ER stress cascades. Contribution of ER stress to the fucoidan-induced cell apoptosis augments our understanding of the molecular mechanisms underlying its antitumour activity and provides evidence for the therapeutic application of fucoidan in cancer.

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U2 - 10.1371/journal.pone.0108157

DO - 10.1371/journal.pone.0108157

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Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades

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