Functional metallosupramolecular architectures using 1,2,3-triazole ligands: it's as easy as 1,2,3 click

Roan A S Vasdev, Dan Preston, James D. Crowley

    Research output: Contribution to journalArticlepeer-review

    60 Citations (Scopus)

    Abstract

    Self-assembled metallosupramolecular architectures have become an increasingly popular area of inorganic chemistry. These systems show a range interesting biological, electronic and photophysical properties. Additionally, they display extensive hostguest chemistry that could potentially be exploited for drug delivery and catalysis. To fully realise these types of applications the ability to generate more functionalised metallosupramolecular architectures is required. In this perspective review we examine the exploitation of 1,2,3-triazole ligands, generated using the Cu(I)-catalysed 1,3-cycloaddition of organic azides with terminal alkynes (the CuAAC click reaction), for the assembly of discrete functional metallosupramolecular architectures. These click ligands have been used to generate metallomacrocycles, cages and helicates. Some of the architectures have shown promise as anti-cancer and anti-bacterial agents while others have been exploited for small molecule activation and catalysis.
    Original languageEnglish
    Pages (from-to)2402-2414
    JournalJournal of the Chemical Society. Dalton Transactions
    Volume46
    Publication statusPublished - 2017

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