GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: A time analysis

Paul B. Fitzgerald; Jerome J. Maller; Kate Hoy; Faranak Farzan; Zafiris J. Daskalakis

doi:10.1016/j.clinph.2009.06.019

GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: A time analysis

Paul B. Fitzgerald^*, Jerome J. Maller, Kate Hoy, Faranak Farzan, Zafiris J. Daskalakis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

Objective: The induction of long interval cortical inhibition (LICI) in motor cortex with paired pulse transcranial magnetic stimulation (ppTMS) is an established paradigm for the assessment of cortical inhibition, proposed to be related to GABA_B receptor inhibitory neurotransmission. This study aimed to further evaluate recent methods of the assessment of LICI in non motor regions with ppTMS and electroencephalography (EEG). Methods: ppTMS was applied using a single coil to the motor and dorsolateral prefrontal cortex (DLPFC) in 14 healthy subjects, and in the parietal lobe in 5 of those subjects. Results: In the motor cortex, LICI resulted in significant suppression in mean cortical evoked activity on EEG between 75 and 250 ms following delivery of the test stimulus. Maximal inhibition was seen from 50 to 250 ms in DLPFC, and between 50 and 175 ms in the parietal lobe. Conclusions: ppTMS may be used to produce LICI in several cortical regions with a time course similar to known GABA_B activity. Significance: ppTMS induction of LICI can be recorded by combining TMS with EEG and seems to relate to GABA_B activity.

Original language	English
Pages (from-to)	1706-1710
Number of pages	5
Journal	Clinical Neurophysiology
Volume	120
Issue number	9
DOIs	https://doi.org/10.1016/j.clinph.2009.06.019
Publication status	Published - 2009
Externally published	Yes

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10.1016/j.clinph.2009.06.019

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@article{ca3e1b5bcaa643e3bac3bb1415cebef6,

title = "GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: A time analysis",

abstract = "Objective: The induction of long interval cortical inhibition (LICI) in motor cortex with paired pulse transcranial magnetic stimulation (ppTMS) is an established paradigm for the assessment of cortical inhibition, proposed to be related to GABAB receptor inhibitory neurotransmission. This study aimed to further evaluate recent methods of the assessment of LICI in non motor regions with ppTMS and electroencephalography (EEG). Methods: ppTMS was applied using a single coil to the motor and dorsolateral prefrontal cortex (DLPFC) in 14 healthy subjects, and in the parietal lobe in 5 of those subjects. Results: In the motor cortex, LICI resulted in significant suppression in mean cortical evoked activity on EEG between 75 and 250 ms following delivery of the test stimulus. Maximal inhibition was seen from 50 to 250 ms in DLPFC, and between 50 and 175 ms in the parietal lobe. Conclusions: ppTMS may be used to produce LICI in several cortical regions with a time course similar to known GABAB activity. Significance: ppTMS induction of LICI can be recorded by combining TMS with EEG and seems to relate to GABAB activity.",

keywords = "Cortical inhibition, Dorsolateral prefrontal cortex, Electroencephalography, GABA, Motor cortex, Parietal cortex, Phase, Transcranial magnetic stimulation",

author = "Fitzgerald, {Paul B.} and Maller, {Jerome J.} and Kate Hoy and Faranak Farzan and Daskalakis, {Zafiris J.}",

year = "2009",

doi = "10.1016/j.clinph.2009.06.019",

language = "English",

volume = "120",

pages = "1706--1710",

journal = "Clinical Neurophysiology",

issn = "1388-2457",

publisher = "Elsevier Ireland Ltd",

number = "9",

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TY - JOUR

T1 - GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG

T2 - A time analysis

AU - Fitzgerald, Paul B.

AU - Maller, Jerome J.

AU - Hoy, Kate

AU - Farzan, Faranak

AU - Daskalakis, Zafiris J.

PY - 2009

Y1 - 2009

N2 - Objective: The induction of long interval cortical inhibition (LICI) in motor cortex with paired pulse transcranial magnetic stimulation (ppTMS) is an established paradigm for the assessment of cortical inhibition, proposed to be related to GABAB receptor inhibitory neurotransmission. This study aimed to further evaluate recent methods of the assessment of LICI in non motor regions with ppTMS and electroencephalography (EEG). Methods: ppTMS was applied using a single coil to the motor and dorsolateral prefrontal cortex (DLPFC) in 14 healthy subjects, and in the parietal lobe in 5 of those subjects. Results: In the motor cortex, LICI resulted in significant suppression in mean cortical evoked activity on EEG between 75 and 250 ms following delivery of the test stimulus. Maximal inhibition was seen from 50 to 250 ms in DLPFC, and between 50 and 175 ms in the parietal lobe. Conclusions: ppTMS may be used to produce LICI in several cortical regions with a time course similar to known GABAB activity. Significance: ppTMS induction of LICI can be recorded by combining TMS with EEG and seems to relate to GABAB activity.

AB - Objective: The induction of long interval cortical inhibition (LICI) in motor cortex with paired pulse transcranial magnetic stimulation (ppTMS) is an established paradigm for the assessment of cortical inhibition, proposed to be related to GABAB receptor inhibitory neurotransmission. This study aimed to further evaluate recent methods of the assessment of LICI in non motor regions with ppTMS and electroencephalography (EEG). Methods: ppTMS was applied using a single coil to the motor and dorsolateral prefrontal cortex (DLPFC) in 14 healthy subjects, and in the parietal lobe in 5 of those subjects. Results: In the motor cortex, LICI resulted in significant suppression in mean cortical evoked activity on EEG between 75 and 250 ms following delivery of the test stimulus. Maximal inhibition was seen from 50 to 250 ms in DLPFC, and between 50 and 175 ms in the parietal lobe. Conclusions: ppTMS may be used to produce LICI in several cortical regions with a time course similar to known GABAB activity. Significance: ppTMS induction of LICI can be recorded by combining TMS with EEG and seems to relate to GABAB activity.

KW - Cortical inhibition

KW - Dorsolateral prefrontal cortex

KW - Electroencephalography

KW - GABA

KW - Motor cortex

KW - Parietal cortex

KW - Phase

KW - Transcranial magnetic stimulation

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DO - 10.1016/j.clinph.2009.06.019

M3 - Article

SN - 1388-2457

VL - 120

SP - 1706

EP - 1710

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 9

ER -

GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: A time analysis

Abstract

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