Ganglion blockade does not prevent cortisol-induced hypertension in man

Paula M. Williamson; Hom Tam Sim; John J. Kelly; Judith A. Whitworth

doi:10.1111/j.1440-1681.2005.04220.x

Ganglion blockade does not prevent cortisol-induced hypertension in man

Paula M. Williamson, Hom Tam Sim, John J. Kelly^*, Judith A. Whitworth

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

1. The aim of the present study was to assess the effect of ganglion blockade on blood pressure in cortisol treated human subjects. 2. Four healthy male subjects were treated with cortisol 80 mg/day for a 5-day period. Ganglion blockade was achieved by intravenous trimethaphan. 3. Ganglion blockade did not significantly alter blood pressure in the pretreatment phase or on the last day of cortisol treatment. 4. Taken together with our previous observations that sympathetic activity is unaltered or reduced by cortisol, these results suggest that cortisol induced hypertension in humans is not a result of overactivity of the autonomic nervous system.

Original language	English
Pages (from-to)	294-296
Number of pages	3
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1111/j.1440-1681.2005.04220.x
Publication status	Published - Apr 2005

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title = "Ganglion blockade does not prevent cortisol-induced hypertension in man",

abstract = "1. The aim of the present study was to assess the effect of ganglion blockade on blood pressure in cortisol treated human subjects. 2. Four healthy male subjects were treated with cortisol 80 mg/day for a 5-day period. Ganglion blockade was achieved by intravenous trimethaphan. 3. Ganglion blockade did not significantly alter blood pressure in the pretreatment phase or on the last day of cortisol treatment. 4. Taken together with our previous observations that sympathetic activity is unaltered or reduced by cortisol, these results suggest that cortisol induced hypertension in humans is not a result of overactivity of the autonomic nervous system.",

keywords = "Blood pressure, Cortisol, Ganglion blockade, Humans, Steroids",

author = "Williamson, {Paula M.} and Sim, {Hom Tam} and Kelly, {John J.} and Whitworth, {Judith A.}",

year = "2005",

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T1 - Ganglion blockade does not prevent cortisol-induced hypertension in man

AU - Williamson, Paula M.

AU - Sim, Hom Tam

AU - Kelly, John J.

AU - Whitworth, Judith A.

PY - 2005/4

Y1 - 2005/4

N2 - 1. The aim of the present study was to assess the effect of ganglion blockade on blood pressure in cortisol treated human subjects. 2. Four healthy male subjects were treated with cortisol 80 mg/day for a 5-day period. Ganglion blockade was achieved by intravenous trimethaphan. 3. Ganglion blockade did not significantly alter blood pressure in the pretreatment phase or on the last day of cortisol treatment. 4. Taken together with our previous observations that sympathetic activity is unaltered or reduced by cortisol, these results suggest that cortisol induced hypertension in humans is not a result of overactivity of the autonomic nervous system.

AB - 1. The aim of the present study was to assess the effect of ganglion blockade on blood pressure in cortisol treated human subjects. 2. Four healthy male subjects were treated with cortisol 80 mg/day for a 5-day period. Ganglion blockade was achieved by intravenous trimethaphan. 3. Ganglion blockade did not significantly alter blood pressure in the pretreatment phase or on the last day of cortisol treatment. 4. Taken together with our previous observations that sympathetic activity is unaltered or reduced by cortisol, these results suggest that cortisol induced hypertension in humans is not a result of overactivity of the autonomic nervous system.

KW - Blood pressure

KW - Cortisol

KW - Ganglion blockade

KW - Humans

KW - Steroids

UR - http://www.scopus.com/inward/record.url?scp=17844377555&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1681.2005.04220.x

DO - 10.1111/j.1440-1681.2005.04220.x

M3 - Article

SN - 0305-1870

VL - 32

SP - 294

EP - 296

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

IS - 4

ER -

Ganglion blockade does not prevent cortisol-induced hypertension in man

Abstract

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