Gasdermin D: The long-awaited executioner of pyroptosis

Si Ming Man; Thirumala Devi Kanneganti

doi:10.1038/cr.2015.124

Gasdermin D: The long-awaited executioner of pyroptosis

Si Ming Man, Thirumala Devi Kanneganti^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

125 Citations (Scopus)

Abstract

Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.

Original language	English
Pages (from-to)	1183-1184
Number of pages	2
Journal	Cell Research
Volume	25
Issue number	11
DOIs	https://doi.org/10.1038/cr.2015.124
Publication status	Published - 1 Nov 2015
Externally published	Yes

Access to Document

10.1038/cr.2015.124

Cite this

@article{73105d7edaf74a18b57aa1408e9058c6,

title = "Gasdermin D: The long-awaited executioner of pyroptosis",

abstract = "Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.",

author = "Man, {Si Ming} and Kanneganti, {Thirumala Devi}",

note = "Publisher Copyright: {\textcopyright} 2015 IBCB, SIBS, CAS.",

year = "2015",

month = nov,

day = "1",

doi = "10.1038/cr.2015.124",

language = "English",

volume = "25",

pages = "1183--1184",

journal = "Cell Research",

issn = "1001-0602",

publisher = "Nature Publishing Group",

number = "11",

}

TY - JOUR

T1 - Gasdermin D: The long-awaited executioner of pyroptosis

AU - Man, Si Ming

AU - Kanneganti, Thirumala Devi

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.

AB - Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.

UR - http://www.scopus.com/inward/record.url?scp=84946489977&partnerID=8YFLogxK

U2 - 10.1038/cr.2015.124

DO - 10.1038/cr.2015.124

M3 - Review article

C2 - 26482951

AN - SCOPUS:84946489977

SN - 1001-0602

VL - 25

SP - 1183

EP - 1184

JO - Cell Research

JF - Cell Research

IS - 11

ER -

Gasdermin D: The long-awaited executioner of pyroptosis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this