Gasdermin D: The long-awaited executioner of pyroptosis

Si Ming Man; Thirumala Devi Kanneganti

doi:10.1038/cr.2015.124

Gasdermin D: The long-awaited executioner of pyroptosis

Si Ming Man, Thirumala Devi Kanneganti^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

140 Citations (SciVal)

Abstract

Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.

Original language	English
Pages (from-to)	1183-1184
Number of pages	2
Journal	Cell Research
Volume	25
Issue number	11
DOIs	https://doi.org/10.1038/cr.2015.124
Publication status	Published - 1 Nov 2015
Externally published	Yes

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10.1038/cr.2015.124

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title = "Gasdermin D: The long-awaited executioner of pyroptosis",

abstract = "Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.",

author = "Man, \{Si Ming\} and Kanneganti, \{Thirumala Devi\}",

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year = "2015",

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AB - Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.

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M3 - Review article

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Gasdermin D: The long-awaited executioner of pyroptosis

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